Long-term detection of dehydrochloromethyltestosterone : one-year experience
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| Deutscher übersetzter Titel: | Der Langzeitnachweis von Dehydrochlormethyltestosteron : ein Jahr Erfahrung |
|---|---|
| Autor: | Sobolevsky, Tim; Rodchenkov, Grigory |
| Erschienen in: | Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop ; 30th Cologne Workshop on Dope Analysis ; 26th February to 2nd March 2012 2. Variante |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2012, S. 34-37, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201308005777 |
| Quelle: | BISp |
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PU201308005777 |
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db |
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Literatur |
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2013-08-09T09:17:24Z |
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2013-08-06T11:22:18Z |
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BISp |
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Sammelwerksbeitrag |
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PU201308005770 |
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PU201308005770 |
| hierarchy_top_title |
Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop ; 30th Cologne Workshop on Dope Analysis ; 26th February to 2nd March 2012 2. Variante |
| hierarchy_parent_title |
Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop ; 30th Cologne Workshop on Dope Analysis ; 26th February to 2nd March 2012 2. Variante |
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PU201308005777 |
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Long-term detection of dehydrochloromethyltestosterone : one-year experience |
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1 |
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bispincollection |
| publishDate |
2012 |
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2012 |
| language |
eng |
| title |
Long-term detection of dehydrochloromethyltestosterone : one-year experience |
| spellingShingle |
Long-term detection of dehydrochloromethyltestosterone : one-year experience Biochemie Doping Dopinganalyse Dopingnachweis Gaschromatographie Langzeitstudie Massenspektrometrie Screening Steroid Testosteron |
| title_sort |
longterm detection of dehydrochloromethyltestosterone oneyear experience |
| title_short |
Long-term detection of dehydrochloromethyltestosterone : one-year experience |
| title_alt |
Der Langzeitnachweis von Dehydrochlormethyltestosteron : ein Jahr Erfahrung |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource |
| city |
Köln |
| abstract |
After more than one year experience in the screening for recently reported dehydrochloromethyltestosterone (DHCMT) metabolites in our laboratory, it was demonstrated that the most long-term is a steroid tentatively characterized as 4-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5β-androst-13-en-3α-ol (M3) and its 17-epimer, which is less abundant but normally always detectable alongside with M3. In the majority of cases, M3 was shown to be superior to the other known DHCMT metabolites, such as 4-chloro-18-nor-17β-hydroxymethyl-17α-methylandrosta-1,4,13-trien-3-one (“night watch” analog) and 4-chloro-3α,6β,17ß-trihydroxy-17α-methyl-5β-androst-1-en-16-one (metabolite “656”). M3 is best detected by gas chromatography - tandem mass spectrometry (GC-MS/MS), whereas GC-MS could still be used but with much less confidence due to both sensitivity and selectivity issues. In 2011 Moscow Antidoping Centre reported twenty five adverse analytical findings (AAF) for DHCMT, of which only 4 would be declared positive based on the presence of 4-chloro-3α,6ß,17ß-trihydroxy-17α-methyl-5ß-androst-1-en-16-one, and only one - if 6ß-hydroxy-DHCMT would be used as the target. In 2012 twenty eight AAFs for DHCMT have already been reported by Moscow Antidoping Centre as of September 1, 2012, with most of them being solely relied on the detection of M3. Therefore, all antidoping laboratories that are capable of running GC-MS/MS technology are advised to include M3 in their screening methods. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
abstract |
| author2 |
Sobolevsky, Tim Rodchenkov, Grigory |
| author_facet |
Sobolevsky, Tim Rodchenkov, Grigory |
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Autor Autor |
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P150940 |
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Sobolevsky, Tim Rodchenkov, Grigory |
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|
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0/Autor/ 1/Autor/Sobolevsky, Tim/ 0/Autor/ 1/Autor/Rodchenkov, Grigory/ |
| publisher |
Sportverl. Strauß |
| publisher-role |
Verlag |
| publisher-address |
Köln |
| publisher-synonym |
|
| publisher-authorityid |
|
| publisher_publisher_facet |
Sportverl. Strauß |
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0/Verlag/ 1/Verlag/Sportverl. Strauß/ |
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0/Deutschland/ 1/Deutschland/Nordrhein-Westfalen/ |
| topic |
Biochemie Doping Dopinganalyse Dopingnachweis Gaschromatographie Langzeitstudie Massenspektrometrie Screening Steroid Testosteron |
| topic_facet |
Biochemie Doping Dopinganalyse Dopingnachweis Gaschromatographie Langzeitstudie Massenspektrometrie Screening Steroid Testosteron |
| spelling |
Biochemie Doping Dopinganalyse Dopingnachweis Gaschromatographie Langzeitstudie Massenspektrometrie Screening Steroid Testosteron biochemistry doping doping analysis doping detection gas chromatography long-term study mass spectrometry screening steroid testosterone Dopingmittel Dopinganalyse Dopinganalytik Leistungstest Langzeitbeobachtung Langzeituntersuchung Langzeittherapie long-term investigation Long-term detection of dehydrochloromethyltestosterone : one-year experience PU201308005777 201308005777 |
| topic_en |
biochemistry doping doping analysis doping detection gas chromatography long-term study mass spectrometry screening steroid testosterone |
| topic_en_facet |
biochemistry doping doping analysis doping detection gas chromatography long-term study mass spectrometry screening steroid testosterone |
| synonym |
Dopingmittel Dopinganalyse Dopinganalytik Leistungstest Langzeitbeobachtung Langzeituntersuchung Langzeittherapie |
| synonym_en |
long-term investigation |
| container_title |
Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop ; 30th Cologne Workshop on Dope Analysis ; 26th February to 2nd March 2012 2. Variante |
| container_start_page |
S. 34-37 |
| container_isbn |
3868840380 |
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1 |
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BISp |
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1810302912521306112 |
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13,263358 |