Long-term detection of dehydrochloromethyltestosterone : one-year experience

Gespeichert in:
Bibliographische Detailangaben
Deutscher übersetzter Titel:Der Langzeitnachweis von Dehydrochlormethyltestosteron : ein Jahr Erfahrung
Autor:Sobolevsky, Tim; Rodchenkov, Grigory
Erschienen in:Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop ; 30th Cologne Workshop on Dope Analysis ; 26th February to 2nd March 2012 2. Variante
Veröffentlicht:Köln: Sportverl. Strauß (Verlag), 2012, S. 34-37, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Sammelwerksbeitrag
Medienart: Gedruckte Ressource
Sprache:Englisch
Schlagworte:
Online Zugang:
Erfassungsnummer:PU201308005777
Quelle:BISp
TY  - COLL
AU  - Sobolevsky, Tim
A2  - Sobolevsky, Tim
A2  - Rodchenkov, Grigory
DB  - BISp
DP  - BISp
KW  - Biochemie
KW  - Doping
KW  - Dopinganalyse
KW  - Dopingnachweis
KW  - Gaschromatographie
KW  - Langzeitstudie
KW  - Massenspektrometrie
KW  - Screening
KW  - Steroid
KW  - Testosteron
LA  - eng
PB  - Sportverl. Strauß
CY  - Köln
TI  - Long-term detection of dehydrochloromethyltestosterone : one-year experience
TT  - Der Langzeitnachweis von Dehydrochlormethyltestosteron : ein Jahr Erfahrung
PY  - 2012
N2  - After more than one year experience in the screening for recently reported dehydrochloromethyltestosterone (DHCMT) metabolites in our laboratory, it was demonstrated that the most long-term is a steroid tentatively characterized as 4-chloro-18-nor-17β-hydroxymethyl-17α-methyl-5β-androst-13-en-3α-ol (M3) and its 17-epimer, which is less abundant but normally always detectable alongside with M3. In the majority of cases, M3 was shown to be superior to the other known DHCMT metabolites, such as 4-chloro-18-nor-17β-hydroxymethyl-17α-methylandrosta-1,4,13-trien-3-one (“night watch” analog) and 4-chloro-3α,6β,17ß-trihydroxy-17α-methyl-5β-androst-1-en-16-one (metabolite “656”). M3 is best detected by gas chromatography - tandem mass spectrometry (GC-MS/MS), whereas GC-MS could still be used but with much less confidence due to both sensitivity and selectivity issues. In 2011 Moscow Antidoping Centre reported twenty five adverse analytical findings (AAF) for DHCMT, of which only 4 would be declared positive based on the presence of 4-chloro-3α,6ß,17ß-trihydroxy-17α-methyl-5ß-androst-1-en-16-one, and only one - if 6ß-hydroxy-DHCMT would be used as the target. In 2012 twenty eight AAFs for DHCMT have already been reported by Moscow Antidoping Centre as of September 1, 2012, with most of them being solely relied on the detection of M3. Therefore, all antidoping laboratories that are capable of running GC-MS/MS technology are advised to include M3 in their screening methods. Verf.-Referat
SP  - S. 34-37
BT  - Recent advances in doping analysis (20) : Proceedings of the Manfred-Donike-Workshop ; 30th Cologne Workshop on Dope Analysis ; 26th February to 2nd March 2012 2. Variante
M3  - Gedruckte Ressource
ID  - PU201308005777
ER  -