Blood glucose responses to reductions in preexercise rapid-acting insulin for 24 h after running in individuals with type 1 diabetes

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Bibliographic Details
Title translated into German:Blutglukoseentwicklung bei Reduzierung der Insulingabe vor körperlicher Belastung für 24 Stunden nach einem Lauf bei Sportlern mit Typ I Diabetes
Author:West, Daniel J.; Morton, Richard D.; Bain, Stephen C.; Stephens, Jeffrey W.; Bracken, Richard M.
Published in:Journal of sports sciences
Published:28 (2010), 7, S. 781-788, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
ISSN:0264-0414, 1466-447X
Online Access:
Identification number:PU201406005266


In this study, we examined pre-exercise insulin reductions on consequent metabolic and dietary patterns for 24 h after running in individuals with type 1 diabetes. Seven participants self-administered their Full rapid-acting insulin dose or 75%, 50% or 25% of it, immediately before consuming a 1.12-MJ meal. After 2 h, participants completed 45 min of running at 70% peak oxygen uptake (VO2peak). Blood glucose and insulin were measured for 2 h before and 3 h after exercise. Blood glucose, diet, and administered insulin were self-recorded for 24 h after exercise. Data were analysed using repeatedmeasures analysis of variance. Pre-exercise peak insulin concentrations were greatest with the Full dose and consequently elicited the lowest blood glucose concentrations (P < 0.05). Blood glucose decreased under all conditions with exercise, with the fall with the Full dose (76.1 mmol * l-1, sx = 0.4) greater than with 25% insulin (73.2 mmol * l-1, sx = 0.4; P < 0.05). There was little change in blood glucose from 0 to 3 h post-exercise under all conditions (P > 0.05). Blood glucose at 3 h post-exercise was greatest with the 25% dose. Over the next 21 h, blood glucose area under the curve was greater with the 25% dose compared with all other trials despite consuming less energy and fewer carbohydrates (P < 0.05). A 75% reduction to pre-exercise insulin results in the greatest preservation of blood glucose, and a reduced dietary intake, for 24 h after running in individuals with type 1 diabetes. Verf.-Referat