Identification of urinary metabolites of exemestane oxidized in the exomethylene group by GC-MS
| Deutscher übersetzter Titel: | Die Identifizierung von in der Exomethylengruppe oxidierten Exemestanmetaboliten im Urin mittels GC-MS |
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| Autor: | Cavalcanti, G.A.; Leal, F.D.; Padilha, M.C.; Pereira, H.M.G.; Torre, X. de la; Aquino Neto, F.R. |
| Erschienen in: | Recent advances in doping analysis (18) : Proceedings of the Manfred-Donike-Workshop ; 28th Cologne Workshop on Dope Analysis , 7th to 12th March 2010 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2010, S. 159-162, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201203002159 |
| Quelle: | BISp |
Abstract
Exemestane (6-methylenandrosta-1,4-diene-3, 17-dione) is a specific steroidal aromatase inhibitor. This class of compounds is often misused to avoid some side effects caused by anabolic steroids and to increase testosterone plasmatic concentration. This drug is extensively metabolized, but 17β-hydroxy-6-methylene-androstadienone (17β-OH-exemestane) is the only metabolite identifïed. The metabolism of exemestane in men is not clearly understood. The 6-exomethylene group undergoes oxidation reactions generating several metabolites not yet described. Buzzetti et al. have synthesized potential exemestane metabolites oxidized in the 6-exomethylene group. The aim at this work was to evaluate new exemestane metabolites oxidized in C6 exomethylene group, using Gas Chromatography coupled to Mass Spectrometry (GC-MS) as the technique of choice. Einleitung