Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage
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Deutscher übersetzter Titel: | Ausdauerbelastung bewirkt eine Interaktion zwischen Stresshormonen, Zytokinen, der Dynamik der Neutrophilen und Muskelkater |
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Autor: | Suzuki, K.; Totsuka, M.; Nakaji, S.; Yamada, M.; Kudoh, S.; Liu, Q.; Sugawara, K.; Yamaya, K.; Sato, K. |
Erschienen in: | Journal of applied physiology |
Veröffentlicht: | 87 (1999), 4, S. 1360-1367, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 8750-7587, 0021-8987, 0161-7567, 1522-1601 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199911402928 |
Quelle: | BISp |
TY - JOUR AU - Suzuki, K. A2 - Suzuki, K. A2 - Totsuka, M. A2 - Nakaji, S. A2 - Yamada, M. A2 - Kudoh, S. A2 - Liu, Q. A2 - Sugawara, K. A2 - Yamaya, K. A2 - Sato, K. DB - BISp DP - BISp KW - Entzündung KW - Granulozyt, neutrophiler KW - Immunologie KW - Katecholamin KW - Kreatinkinase KW - Muskelkater KW - Myoglobin KW - Myolyse KW - Skelettmuskulatur KW - Sportmedizin KW - Wachstumshormon KW - Zytokine LA - eng TI - Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage TT - Ausdauerbelastung bewirkt eine Interaktion zwischen Stresshormonen, Zytokinen, der Dynamik der Neutrophilen und Muskelkater PY - 1999 N2 - We analyzed adaptation mechanisms regulating systemic inflammatory response of the stressed body by using an experimental challenge of repeated exercise bouts and accompanying muscle inflammation. Eight untrained men bicycled at 90 W for 90 min, 3 days in a row. Exercise induced peripheral neutrophilia with a leftward shift of neutrophil nucleus and neutrophil priming for oxidative activity determined by luminol-dependent chemiluminescence. Plasma growth hormone and interleukin-6 rose significantly after exercise and were closely correlated with the neutrophil responses. Serum creatine kinase and myoglobin levels as muscle damage markers rose after exercise in "delayed onset" and were closely correlated with the preceding neutrophil responses. These exercise-induced responses were strongest on day 1, but the magnitude gradually decreased with progressive daily exercise. In contrast, the magnitude of catecholamine responses to exercise sessions gradually rose, possibly suppressing neutrophil oxidative responses. These results indicate that stress-induced systemic release of bioactive substances may determine neutrophil mobilization and functional status, which then may affect local tissue damage of susceptible organs. Verf.-Referat SP - S. 1360-1367 SN - 8750-7587 JO - Journal of applied physiology IS - 4 VL - 87 M3 - Gedruckte Ressource ID - PU199911402928 ER -