Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury
Deutscher übersetzter Titel: | Ibuprofen in entzuendungshemmender Dosierung: Auswirkung auf Neutrophile und belastungsbedingte Muskelschaedigung |
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Autor: | Pizza, F.X.; Cavender, D.; Stockard, A.; Baylies, H.; Beighle, A. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 20 (1999), 2, S. 98-102, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-1999-970272 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199903307655 |
Quelle: | BISp |
Abstract des Autors
The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2-. production, and markers of muscle injury. Males (n=10) performed 2 bouts of one-arm eccentric exercise on opposite arms separated by three weeks. Subjects received 2400 mg/d of ibuprofen or a placebo 5 d before exercise and during 10 d of recovery. Measurements were made before the treatments, pre-exercise, at 4 h, and at 1, 2, 3, 4 and 10 d postexercise. Circulating neutrophil counts were similar between the treatments at the sampling points. Neutrophil counts were higher (p<0.05) for ibuprofen and were elevated (p<0.05) at 4 h post-exercise relative to pre-exercise in both treatments. Stimulated neutrophil O2-. production was lower for ibuprofen relative to placebo at pre-exercise and was increased (p<0.05) at 4 h and 4 d of both treatments. CK activity at 3 d post-exercise was lower (p<0.05) for ibuprofen relative to placebo. Isometric strength, soreness, tenderness, and arm angles were similar between the treatments. In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise. Verf.-Referat