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Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration

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Deutscher übersetzter Titel:Somatostatin dämpft die durch Hyperthermie induzierte Erhöhung der Neutrophilenkonzentration
Autor:Kappel, M.; Poulsen, T.D.; Hansen, M.B.; Galbo, H.; Pedersen, B.K.
Erschienen in:European journal of applied physiology
Veröffentlicht:77 (1997), 1-2, S. 149-156, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Englisch
ISSN:1439-6319, 0301-5548
DOI:10.1007/s004210050313
Schlagworte:
Granulozyt, neutrophiler
Hyperthermie
Immunologie
Immunsystem
Leukozytose
Sportmedizin
Wachstumshormon
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Erfassungsnummer:PU199801208887
Quelle:BISp
id PU199801208887
bisp-collection db
format Literatur
last_indexed 2023-01-10T16:04:09Z
first_indexed 2001-07-24T13:38:22Z
publication_source BISp
subformat Zeitschriftenartikel
hierarchy_top_id JO00000100345
hierarchy_parent_id JOI199798c60100345
hierarchy_top_title European journal of applied physiology
hierarchy_parent_title European journal of applied physiology, 1997, 1-2
is_hierarchy_id PU199801208887
is_hierarchy_title Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
hierarchy_sequence 0149
recordtype bisparticle
publishDate 1997
publishDate_facet 1997
language eng
title Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
spellingShingle Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
Granulozyt, neutrophiler
Hyperthermie
Immunologie
Immunsystem
Leukozytose
Sportmedizin
Wachstumshormon
title_sort somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
title_short Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
title_alt Somatostatin dämpft die durch Hyperthermie induzierte Erhöhung der Neutrophilenkonzentration
title_alt_lang deu
media_type Gedruckte Ressource
Elektronische Ressource (online)
city Berlin
abstract This study was designed to test the hypothesis that the immune changes seen during in vivo whole body hyperthermia are mediated by elevations in the plasma concentrations of either catecholamines, growth hormone or beta-endorphins. Eight healthy volunteers were immersed in a hot water bath (WI; water temperature 39.5øC) for 2 h during which their rectal temperature rose to 39.5øC. In a single blind, randomized, cross-over study the stress hormone effects were blocked one at a time by administration of propranolol, somatostatin or naloxone; the results were compared to those obtained during saline infusion (control). Blood samples were collected before, at the end of 2 h of WI (body temperature 39.5øC), and 2 h later. Hormone blockade did not abolish the hyperthermia-induced recruitment of natural killer (NK) cells to the blood, and no influence was observed on the percentages or concentrations of any other subpopulations of blood mononuclear cells, except that the number of cluster designation (CD)3+ cells slightly increased after hyperthermia only in the propranolol experiment. Furthermore, the NK cell activity, both unstimulated and interferon-alpha or interleukin-2 stimulated, did not differ from the control situation. It is of interest, however, that somatostatin partly abolished the hyperthermia induced increase in the neutrophil number. Based on these data and previous results showing that growth hormone infusion increases the concentration of neutrophils in the blood, it is suggested that growth hormone is at least partly responsible for hyperthermia induced neutrocytosis. Verf.-Referat
abstract_lang eng
abstract_type author
author2 Kappel, M.
Poulsen, T.D.
Hansen, M.B.
Galbo, H.
Pedersen, B.K.
author_facet Kappel, M.
Poulsen, T.D.
Hansen, M.B.
Galbo, H.
Pedersen, B.K.
author2-role Autor
Autor
Autor
Autor
Autor
author2-authorityid




author_author_facet Kappel, M.
Poulsen, T.D.
Hansen, M.B.
Galbo, H.
Pedersen, B.K.
author2-synonym




author2_hierarchy_facet 0/Autor/
1/Autor/Kappel, M./
0/Autor/
1/Autor/Poulsen, T.D./
0/Autor/
1/Autor/Hansen, M.B./
0/Autor/
1/Autor/Galbo, H./
0/Autor/
1/Autor/Pedersen, B.K./
doi 10.1007/s004210050313
spelling 10.1007/s004210050313
1439-6319
0301-5548
EJAPC
124793-1
Granulozyt, neutrophiler
Hyperthermie
Immunologie
Immunsystem
Leukozytose
Sportmedizin
Wachstumshormon
growth hormone
hyperthermia
immune system
immunology
leukocytosis
neutrophil
sports medicine
Fieber
Abwehr, körpereigene
Abwehrmechanismus
Medizin
Geschichte der Medizin
Untersuchung, sportmedizinische
Wasserdampf
fever
somatotropic hormone
somatotropin
STH
immunological system
Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
PU199801208887
199801208887
url https://dx.doi.org/10.1007/s004210050313
url-type fulltext
url-free 1
free_access 1
issn 1439-6319
0301-5548
coden EJAPC
zdb 124793-1
location_hierarchy_facet 0/Deutschland/
1/Deutschland/Berlin/
topic Granulozyt, neutrophiler
Hyperthermie
Immunologie
Immunsystem
Leukozytose
Sportmedizin
Wachstumshormon
topic_facet Granulozyt, neutrophiler
Hyperthermie
Immunologie
Immunsystem
Leukozytose
Sportmedizin
Wachstumshormon
topic_en growth hormone
hyperthermia
immune system
immunology
leukocytosis
neutrophil
sports medicine
topic_en_facet growth hormone
hyperthermia
immune system
immunology
leukocytosis
neutrophil
sports medicine
synonym Fieber
Abwehr, körpereigene
Abwehrmechanismus
Medizin
Geschichte der Medizin
Untersuchung, sportmedizinische
Wasserdampf
synonym_en fever
somatotropic hormone
somatotropin
STH
immunological system
journal_facet European journal of applied physiology
container_title European journal of applied physiology
container_volume 77
container_issue 1-2
container_start_page S. 149-156
has_references 1
institution BISp
journal_fac JO00000100345
journal_year 1997
journal_issue 1-2
_version_ 1791517009126621184
score 13,558404

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