Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration
Gespeichert in:
Deutscher übersetzter Titel: | Somatostatin dämpft die durch Hyperthermie induzierte Erhöhung der Neutrophilenkonzentration |
---|---|
Autor: | Kappel, M.; Poulsen, T.D.; Hansen, M.B.; Galbo, H.; Pedersen, B.K. |
Erschienen in: | European journal of applied physiology |
Veröffentlicht: | 77 (1997), 1-2, S. 149-156, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 1439-6319, 0301-5548 |
DOI: | 10.1007/s004210050313 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199801208887 |
Quelle: | BISp |
TY - JOUR AU - Kappel, M. A2 - Kappel, M. A2 - Poulsen, T.D. A2 - Hansen, M.B. A2 - Galbo, H. A2 - Pedersen, B.K. DB - BISp DP - BISp KW - Granulozyt, neutrophiler KW - Hyperthermie KW - Immunologie KW - Immunsystem KW - Leukozytose KW - Sportmedizin KW - Wachstumshormon LA - eng TI - Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration TT - Somatostatin dämpft die durch Hyperthermie induzierte Erhöhung der Neutrophilenkonzentration PY - 1997 N2 - This study was designed to test the hypothesis that the immune changes seen during in vivo whole body hyperthermia are mediated by elevations in the plasma concentrations of either catecholamines, growth hormone or beta-endorphins. Eight healthy volunteers were immersed in a hot water bath (WI; water temperature 39.5øC) for 2 h during which their rectal temperature rose to 39.5øC. In a single blind, randomized, cross-over study the stress hormone effects were blocked one at a time by administration of propranolol, somatostatin or naloxone; the results were compared to those obtained during saline infusion (control). Blood samples were collected before, at the end of 2 h of WI (body temperature 39.5øC), and 2 h later. Hormone blockade did not abolish the hyperthermia-induced recruitment of natural killer (NK) cells to the blood, and no influence was observed on the percentages or concentrations of any other subpopulations of blood mononuclear cells, except that the number of cluster designation (CD)3+ cells slightly increased after hyperthermia only in the propranolol experiment. Furthermore, the NK cell activity, both unstimulated and interferon-alpha or interleukin-2 stimulated, did not differ from the control situation. It is of interest, however, that somatostatin partly abolished the hyperthermia induced increase in the neutrophil number. Based on these data and previous results showing that growth hormone infusion increases the concentration of neutrophils in the blood, it is suggested that growth hormone is at least partly responsible for hyperthermia induced neutrocytosis. Verf.-Referat L2 - https://dx.doi.org/10.1007/s004210050313 DO - 10.1007/s004210050313 SP - S. 149-156 SN - 1439-6319 JO - European journal of applied physiology IS - 1-2 VL - 77 M3 - Gedruckte Ressource M3 - Elektronische Ressource (online) ID - PU199801208887 ER -