Somatostatin attenuates the hyperthermia induced increase in neutrophil concentration

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Bibliographic Details
Title translated into German:Somatostatin daempft die durch Hyperthermie induzierte Erhoehung der Neutrophilenkonzentration
Author:Kappel, M.; Poulsen, T.D.; Hansen, M.B.; Galbo, H.; Pedersen, B.K.
Published in:European journal of applied physiology
Published:77 (1998), 1-2 , S. 149-156, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
Language:English
ISSN:1439-6319, 0301-5548
Keywords:
Online Access:
Identification number:PU199801208887
Source:BISp

Author's abstract

This study was designed to test the hypothesis that the immune changes seen during in vivo whole body hyperthermia are mediated by elevations in the plasma concentrations of either catecholamines, growth hormone or beta-endorphins. Eight healthy volunteers were immersed in a hot water bath (WI; water temperature 39.5øC) for 2 h during which their rectal temperature rose to 39.5øC. In a single blind, randomized, cross-over study the stress hormone effects were blocked one at a time by administration of propranolol, somatostatin or naloxone; the results were compared to those obtained during saline infusion (control). Blood samples were collected before, at the end of 2 h of WI (body temperature 39.5øC), and 2 h later. Hormone blockade did not abolish the hyperthermia-induced recruitment of natural killer (NK) cells to the blood, and no influence was observed on the percentages or concentrations of any other subpopulations of blood mononuclear cells, except that the number of cluster designation (CD)3+ cells slightly increased after hyperthermia only in the propranolol experiment. Furthermore, the NK cell activity, both unstimulated and interferon-alpha or interleukin-2 stimulated, did not differ from the control situation. It is of interest, however, that somatostatin partly abolished the hyperthermia induced increase in the neutrophil number. Based on these data and previous results showing that growth hormone infusion increases the concentration of neutrophils in the blood, it is suggested that growth hormone is at least partly responsible for hyperthermia induced neutrocytosis. Verf.-Referat