Modulation der beta-Adrenozeptoren im Rattenherzen durch Training und Belastung
| Englischer übersetzter Titel: | Modulation of beta-adrenoceptors in rat cardiomyocytes by training and exercise |
|---|---|
| Autor: | Werle, E.; Huber, K.H.; Biehl, K.; Herth, C.; Weicker, H. |
| Herausgeber: | Boening, D.; Braumann, Klaus-Michael; Busse, M.W.; Maassen, Norbert; Schmidt, W. |
| Erschienen in: | Sport - Rettung oder Risiko für die Gesundheit? 31. Deutscher Sportärztekongress, Hannover 1988 |
| Veröffentlicht: | Köln: Dt. Ärzte-Verl. (Verlag), 1989, 1989. S. 162-165, Abb., Lit., Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Gedruckte Ressource |
| Sprache: | Deutsch |
| ISBN: | 3769101952 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199411074319 |
| Quelle: | BISp |
Abstract des Autors
The number of cardiac beta-adrenoceptors of endurance (ATUB) and power trained (MTUB) rats has been compared with untrained animals at rest (UTUB) and after endurance exercise (UTAB). Binding experiments have been performed with the radiotracer 125I-cyanopindolol (ICYP) at 4 deg C for 18 h in order to maintain short term receptor regulations which may be reversible at higher incubation temperatures. Coanalysis of saturation binding data of the control animals with the computer program LIGAND yielded a high affinity binding site with a dissociation constant (KD) of 11.7 pM and a beta-adrenoceptor number (Bmax) of 43.2 fmol/mg protein. As compared to the controls, the cardiac beta-adrenoceptor number of the UTAB, ATUB and MTUB animals was lower by 17.4%, 12.7%, and 25.5%, respectively. Verf.-Referat