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Impaired responses of catecholamines, growth hormone, and cortisol to graded exercise in diabetic autonomic neuropathy

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Title translated into German:Schwaechere Reaktionen von Katecholaminen, Wachstumshormon und Kortisol auf abgestufte koerperliche Belastung bei autonomer diabetischer Neuropathie
Author:Hilsted, Jannik; Galbo, Henrik; Christensen, Niels Juel
Published in:Diabetes
Published:29 (1980), 4 , S. 257-262, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
Language:English
ISSN:0012-1797, 1939-327X
Keywords:
adrenaline
bicycle ergometer load
catecholamine
cortisol
diabetes, juvenile
diabetes mellitus
endocrinium
exhaustion
free fatty acid
glucagon
glucose
glycerin
growth hormone
heart rate
hormone
insulin
lactate
maximal oxygen uptake
metabolism
nervous system
neuropathy
noradrenaline
physical load
sports medicine
ventilation
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Identification number:PU198106014712
Source:BISp
TY  - JOUR
AU  - Hilsted, Jannik
A2  - Hilsted, Jannik
A2  - Galbo, Henrik
A2  - Christensen, Niels Juel
DB  - BISp
DP  - BISp
KW  - Adrenalin
KW  - Belastung, körperliche
KW  - Diabetes, juveniler
KW  - Diabetes mellitus
KW  - Endokrinium
KW  - Erschöpfung
KW  - Fahrradergometerbelastung
KW  - Fettsäure, freie
KW  - Glukagon
KW  - Glukose
KW  - Glyzerin
KW  - Herzfrequenz
KW  - Hormon
KW  - Insulin
KW  - Katecholamin
KW  - Kortisol
KW  - Laktat
KW  - Nervensystem
KW  - Neuropathie
KW  - Noradrenalin
KW  - Sauerstoffaufnahme, maximale
KW  - Sportmedizin
KW  - Stoffwechsel
KW  - Ventilation
KW  - Wachstumshormon
LA  - eng
TI  - Impaired responses of catecholamines, growth hormone, and cortisol to graded exercise in diabetic autonomic neuropathy
TT  - Schwaechere Reaktionen von Katecholaminen, Wachstumshormon und Kortisol auf abgestufte koerperliche Belastung bei autonomer diabetischer Neuropathie
PY  - 1980
N2  - Six juvenile diabetics (age, 31 +/- 2 yr (x and SEM) duration of diabetes, 15 +/- 4 yr), who showed signs of autonomic neuropathy (decreased beat-to-beat variation in heart rate during deep breathing), and seven control patients of similar age (27 +/- 1 yr) and duration of diabetes (14 +/- 2 yr) performed graded exercise on an ergometer cycle 3 h after breakfast and subcutaneous administration of insulin. Plasma epinephrine increased significantly in both patients groups and was not significantly different at exhaustion (0.43 +/- 0.17 ng/ml (neuropathy) vs. 1.07 +/- 0.28 ng/ml (controls), (P< 0.1). Plasma norepinephrine levels increased significantly in controlpatients but not in autonomic neuropathy, and they were significantly different at exhaustion (1.43 +/- 0.34 ng/ml (neuropathy) vs. 2.51 +/- 0.26 ng/ml (controls), P<0.05). The relationships between plasma norepinephrine and epinephrine levels, respectively, and relative work load (expressed as oxygen uptake-in percent-of individual maximal oxygen uptake) were shifted to the right in patients with autonomic neuropathy, indicating impaired sympathetic activity. In conclusion, diabetics with decreased beat-to-beat variation in heart rate displayed impaired responses of catecholamines, indicating a defective sympathoadrenal outflow, and of other glucoregulatory hormones during graded exercise. Verf.-Referat (gekuerzt)
SP  - S. 257-262
SN  - 0012-1797
JO  - Diabetes
IS  - 4
VL  - 29
M3  - Gedruckte Ressource
ID  - PU198106014712
ER  -

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