Impaired responses of catecholamines, growth hormone, and cortisol to graded exercise in diabetic autonomic neuropathy

Saved in:
Bibliographic Details
Title translated into German:Schwaechere Reaktionen von Katecholaminen, Wachstumshormon und Kortisol auf abgestufte koerperliche Belastung bei autonomer diabetischer Neuropathie
Author:Hilsted, Jannik; Galbo, Henrik; Christensen, Niels Juel
Published in:Diabetes
Published:29 (1980), 4 , S. 257-262, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
ISSN:0012-1797, 1939-327X
Online Access:
Identification number:PU198106014712


Six juvenile diabetics (age, 31 +/- 2 yr (x and SEM) duration of diabetes, 15 +/- 4 yr), who showed signs of autonomic neuropathy (decreased beat-to-beat variation in heart rate during deep breathing), and seven control patients of similar age (27 +/- 1 yr) and duration of diabetes (14 +/- 2 yr) performed graded exercise on an ergometer cycle 3 h after breakfast and subcutaneous administration of insulin. Plasma epinephrine increased significantly in both patients groups and was not significantly different at exhaustion (0.43 +/- 0.17 ng/ml (neuropathy) vs. 1.07 +/- 0.28 ng/ml (controls), (P< 0.1). Plasma norepinephrine levels increased significantly in controlpatients but not in autonomic neuropathy, and they were significantly different at exhaustion (1.43 +/- 0.34 ng/ml (neuropathy) vs. 2.51 +/- 0.26 ng/ml (controls), P<0.05). The relationships between plasma norepinephrine and epinephrine levels, respectively, and relative work load (expressed as oxygen uptake-in percent-of individual maximal oxygen uptake) were shifted to the right in patients with autonomic neuropathy, indicating impaired sympathetic activity. In conclusion, diabetics with decreased beat-to-beat variation in heart rate displayed impaired responses of catecholamines, indicating a defective sympathoadrenal outflow, and of other glucoregulatory hormones during graded exercise. Verf.-Referat (gekuerzt)