Investigations on the deconjugation processes of conjugated urinary steroids during degradation with 18O labelled water
Gespeichert in:
| Deutscher übersetzter Titel: | Untersuchungen des Dekonjugationsprozesses von konjugierten Steroiden im Urin während des Abbaus unter Verwendung von 18O-Wasser |
|---|---|
| Autor: | Piper, Thomas; Fußhöller, Gregor; Schänzer, Wilhelm |
| Erschienen in: | Recent advances in doping analysis (19) : Proceedings of the Manfred-Donike-Workshop ; 29th Cologne Workshop on Dope Analysis ; 13th to 18th February 2011 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2011, S. 296-299, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (Datenträger) |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201211007424 |
| Quelle: | BISp |
Abstract
Recent investigations on the influence of urinary degradation on carbon isotope ratios (CIR) of endogenous steroids showed a strong shift in CIR of unconjugated steroids especially at the beginning of deconjugation. The difference between conjugated steroids (gluco- and sulfo-conjugates) and free steroids was found to be more than l‰. This finding was surprising as it is generally assumed that deconjugation occurs without involvement of the steroidal backbone. Both glucuronides and sulfates should be cleaved under retention of the oxygen atom at the steroid. In contrast, a cleavage occurring between the steroid and the oxygen could help explaining the found isotopic fractionation accompanied by degradation. Einleitung