TY  - JOUR
AU  - Gomes, R.J.
A2  - Gomes, R.J.
A2  - Caetano, F.H.
A2  - Mello, M.A.R.
A2  - Luciano, E.
DB  - BISp
DP  - BISp
KW  - Aktivität, körperliche
KW  - Blutuntersuchung
KW  - Diabetes mellitus
KW  - Hormonausschüttung
KW  - Hormonhaushalt
KW  - Schwimmen
KW  - Sportmedizin
KW  - Tierversuch
KW  - Training, sportliches
KW  - Untersuchung, vergleichende
KW  - Wachstumshormon
LA  - eng
TI  - Influence of moderate physical training on the GH/IGF-1 axis in diabetic rats
TT  - Einfluss moderater körperliche Aktivität auf die GH/IGF-1 Achse bei Ratten mit Diabetes
PY  - 2006
N2  - The influence of moderate physical training on serum growth hormone (GH), insulin-like growth factor –1 (IGF-1) and binding protein ( IGFBP-3) in experimental diabetic rats was investigated. Male Wistar rats were divided into 4 groups, sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). Experimental diabetes was induced of Alloxan (35mg/b.w.) The training program consisted by swimming 5 days/week, 1 h/day, supporting a load of 2.5 % b.w., during 6 weeks. Then, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, GH, IGF-1 and IGFBP-3. Samples of liver were used to evaluate glycogen, protein and DNA contents. The results were analyzed by ANOVA, and Bonferroni test and the significance level was set at 2.5 %. Diabetes decreased serum GH, IGF-1, IGFBP-3 and liver glycogen stores in SD group. Physical training promoted increase in serum IGF-1 in both TC and TD groups (SC=82 ± 15; TC=103 ± 13; SD=77 ± 16; TD=112 ± 29 ng/ml) and liver glycogen store in TD group when compared to SD (SC=5.2 ± 1.2; TC= 6.2 ± 1; SD=2 ± 0.5; TD=5 ± 1.8 mg/100mg). Therefore, physical training contributes to the increase in liver glycogen content and to rise of insulin-like growth factor level in diabetic rats. It was concluded that moderate physical training promotes important adaptations related to GH-IGF-1 axis in diabetic organisms. Verf.-Referat
L2  - http://biolsport.com/fulltxt.php?ICID=890842
SP  - S. 291-301
SN  - 0860-021X
JO  - Biology of sport
IS  - 3
VL  - 23
M3  - Elektronische Ressource (online)
M3  - Gedruckte Ressource
ID  - PU201101000809
ER  -