Time-Of-Flight mass spectrometry : unification of analytical methods and preventive screening in doping control analysis
Gespeichert in:
| Deutscher übersetzter Titel: | Time of flight Massenspektrometrie : die Vereinigung von analytischen Methoden und präventivem Screening in der Dopinganalytik |
|---|---|
| Autor: | Kioussi, X.; Fragkaki, A.; Vonaparti, A.; Stamou, M.; Demesticha, M.; Lyris, E.; Angelis, Y.S. ; Tsoupras, G.; Wuest, B.; Nielen, M.W.F.; Panderi, I.; Koupparis, M.; Georgakopoulos, C. |
| Erschienen in: | Recent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis ; 25th February to 2nd March 2007 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2007, S. 235-244, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201001000319 |
| Quelle: | BISp |
Abstract
The evolution of Time-Of-Flight (TOF) technology in the fields of electronics and hardware geometry (orthogonal acceleration, reflectron) resulted in an improved mass accuracy and good sensitivity in scan mode. In other analytical fields, like food, the use of TOF instruments is extensive, but not in doping control analysis. Our approach in the use of TOF technology comprises two main axes: 1. Unification of the gas and liquid chromatographic/mass spectrometric procedures using one hydrolysis step, common extraction step, one derivatisation procedure for the aliquots that are designated to be injected in GC instruments and, finally, the underivatised aliquot of the same sample to be injected to LC instrument. 2. Preventive screening for designer steroids using CG/TOF/MS and LC/TOF/MS analysis. Since the project is supported by an ongoing 3 years (2005-2008) grant from WADA, the present study will cover the parts of the entire task, together with data showing the combined screening of LC/TOF/MS and GC/TOF/MS for the prevention of designer steroids abuse. Verf.-Referat