Detection of mepitiostane in doping analysis

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Bibliographische Detailangaben
Deutscher übersetzter Titel:Der Nachweis von Mepitiostan in der Dopinganalytik
Autor:Okano, Masato; Ikekita, Ayako; Sato, Mitsuhiko; Kageyama, Shinji
Erschienen in:Recent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis ; 25th February to 2nd March 2007
Veröffentlicht:Köln: Sportverl. Strauß (Verlag), 2007, S. 123-132, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Sammelwerksbeitrag
Medienart: Elektronische Ressource (online) Gedruckte Ressource
Sprache:Englisch
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Erfassungsnummer:PU201001000303
Quelle:BISp

Abstract

Mepitiostane and epitiostanol are not mentioned in the WADA prohibited List in 2007. There were no reports concerning the abuse of this substance by athletes, however, it is possible that some athletes use them for doping purposes. Therefore the aim of this study was to establish adequate GC/MS and LC/MS parameters for the screening of mepitiostane and also to start the screening in routine doping tests. Conclusion: The common steroid screening procedure by GC/MS is suitable for the detection of mepitiostan abuse, and then the target substance should be 2,(5α)-androsten-17ß-ol as TMS derivative. The detection of specific metabolite epitiostanol by LC/MS in APPI-mode could be proposed for the confirmation analysis. The mentioned analytical methods for the hydroxy-metabolites are still in investigation. Aus dem Text (geändert)