The detection of the misuse of testosterone gel
Gespeichert in:
| Deutscher übersetzter Titel: | Der Nachweis des Missbrauchs von Testosterongel |
|---|---|
| Autor: | Geyer, Hans; Flenker, U.; Mareck, U.; Platen, Petra; Piper, T.; Schmechel, A.; Schrader, Y.; Thevis, Mario; Schänzer, Wilhelm |
| Erschienen in: | Recent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis ; 25th February to 2nd March 2007 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2007, S. 133-142, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201001000301 |
| Quelle: | BISp |
Abstract
To develop a method for the detection of the misuse of testosterone gel (T-gel) 18 healthy male volunteers were treated for six weeks continuously and intermittently with T-gel (100 mg testosterone per day). Blood and urine samples were collected before, during and after the application of T-gel. The following results were obtained. The treatment with T-gel leads to an increase of serum testosterone and a decrease of LH. The most discriminating parameters of the steroid profile are the ratios testosterone/epitestosterone, 5α-androstane-3 α,17ß-diol / epitestosterone and androsterone/epitestosterone. Individual reference ranges of the parameters are more suitable for the detection of the misuse of T-gel than population based reference ranges. For the GC/C/IRMS analysis suitable target compounds are testosterone and 5α -androstane-3 α,17ß-diol. Verf.-Referat