A polymorphism in the alpha2a-adrenoceptor gene and endurance athlete status
Deutscher übersetzter Titel: | Polymorphismus des alpha2a-Adrenozeptor-Gens und ausdauersportliches Potential |
---|---|
Autor: | Wolfarth, Bernd; Rivera, M.A.; Oppert, J.M.; Boulay, M.R.; Dionne, F.T.; Chagnon, M.; Gagnon, J.; Chagnon, Y.; Perusse, L.; Keul, Joseph; Bouchard, C. |
Erschienen in: | Medicine and science in sports and exercise |
Veröffentlicht: | 32 (2000), 10, S. 1709-1712, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0195-9131, 1530-0315 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199912408963 |
Quelle: | BISp |
Abstract des Autors
Purpose: In a case control study, we examined the allelic frequencies and genotype distributions of two restricted fragment length polymorphisms (RFLP) in the alpha-2A-adrenoceptor gene (ADRA2A) and beta-2-adrenoceptor gene (ADRB2) among elite endurance athletes (EEA) and sedentary controls (SC). Methods: The EEA group included 148 Caucasian male subjects recruited on the basis that they had a VO2max >74 mL O2/kg/min. The SC group comprised 149 unrelated sedentary male subjects, all Caucasians, from the Quebec Family Study. After digestion with the restriction enzymes Dra I (ADRA2A) and Ban I (ADRB2), Southern blotting and hybridization techniques were used to detect the mutations in the two ADR genes, which are encoded on chromosomes 10 (q24-26) and 5 (q31-32), respectively. Results: For the Dra I ADRA2A RFLP, we observed a significant difference in genotype distributions between the two groups (P=0.037). A higher frequency of the 6.7-kb allele was observed in the EEA group compared with the SC group (P=0.013). No statistically significant difference was found between groups for the Ban I ADRB2 polymorphic site. Genotype frequencies for both genes in both groups were in Hardy-Weinberg equilibrium. Conclusions: In summary, we found evidence that ADRA2A gene variability detected with Dra I is weakly associated with elite endurance athlete status, and we conclude that genetic variation in the ADRA2A gene or a locus in close proximity may play a role in being able to sustain the endurance training regimen necessary to attain a high level of maximal aerobic power. Verf.-Referat