No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status
Deutscher übersetzter Titel: | Keine Beziehung zwischen dem ACE-ID-Polymorphismus und der Leistungsfaehigkeit von Spitzen-Ausdauersportlern |
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Autor: | Rankinen, T.; Wolfarth, Bernd; Simoneau, J.A.; Maier-Lenz, D.; Rauramaa, R.; Rivera, M.A.; Boulay, M.R.; Chagnon, Y.C.; Perusse, L.; Keul, Joseph; Bouchard, C. |
Erschienen in: | Journal of applied physiology |
Veröffentlicht: | 88 (2000), 5, S. 1571-1575, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 8750-7587, 0021-8987, 0161-7567, 1522-1601 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199912407443 |
Quelle: | BISp |
Abstract des Autors
Several studies have reported that the insertion (I) allele of the angiotensin-converting enzyme (ACE) I/deletion (D) polymorphism is associated with enhanced responsiveness to endurance training and is more common in endurance athletes than in sedentary controls. We tested the latter hypothesis in a cohort of 192 male endurance athletes with maximal oxygen uptake >/=75 ml/kg/min and 189 sedentary male controls. The ACE ID polymorphism in intron 16 was typed with the three-primer polymerase chain reaction method. Both the genotype (P=0.214) and allele (P=0.095) frequencies were similar in the athletes and the controls. Further analyses in the athletes revealed no excess of the I allele among the athletes within the highest quartile (>80 mI/kg/min) or decile (>83 ml/kg/min) of maximal oxygen uptake. These data from the GEN-ATHLETE cohort do not support the hypothesis that the ACE ID polymorphism is associated with a higher cardiorespiratory endurance performance level. Verf.-Referat