Abstract des Autors

As the catecholamine sulfates (CA-S) amount to 60-95% of the total plasma catecholamines, they ought to be given consideration in the evaluation of the sympathoadrenergic regulation. After the method of their detection was improved and the chemically authentic reference compounds of CA-S isomers and L-dopa-S were synthesized, the physiologic properties were elucidated during discipline-specific exercise of runners, swimmers, and rowers. In case of inadequate CA release, the 3-O-S isomers prevent a receptor stimulation since CA-S are no ligands of adrenoceptors and arylsulfatase has a low affinity to 3-O-S isomers. In contrast, the 4-O-S isomers are predominantly deconjugated by arylsulfatases at lowered pH, which liberates CA without neuronal release or secretion from the adrenal medulla: The functions of phenolsulfotransferase (PST), its sulfate donor (PAPS), and arylsulfatases are discussed. Verf.-Referat