Exercise-induced changes in the expression of surface adhesion molecules on circulating granulocytes and lymphocytes subpopulations
Deutscher übersetzter Titel: | Belastungsbedingte Veränderungen in der Expression der Adhäsionsmoleküle der zirkulierenden Granulozyten und Lymphozytensubpopulationen |
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Autor: | Kurokawa, Y.; Shinkai, S.; Hino, S.; Shek, P.N.; Torii, J. |
Erschienen in: | European journal of applied physiology |
Veröffentlicht: | 71 (1995), 2/3, S. 245-252, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 1439-6319, 0301-5548 |
DOI: | 10.1007/BF00854986 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199509102790 |
Quelle: | BISp |
Abstract des Autors
This study examined the relationship between exercise-induced changes in the concentration of circulating immunocompetent cells and their surface expression of adhesion molecules: L-selectin (CD62L) and three beta2-integrins (LFA-1(CD11a/CD18), Mac-1(CD11b/CD18), and p150/95(CD11c/CD18)). Eight young male volunteers exercised on a cycle ergometer for 60 min at 60% maximal oxygen uptake. Peripheral blood samples, collected every 30 min throughout exercise and during the 2-h recovery period, were used for flow-cytometric analysis. The experimental results were compared with control data obtained ever 60 min at corresponding times of the nonexercise day. The exercise regimen induced a granulocytosis and a lymphocytosis, mainly due to an elevation of CD8+ and CD16+ cells. During recovery, a further granulocytosis occurred but accompanied by a lymphopenia. The increased CD8+ cell-count during exercise was characterized by a selective mobilization of the CD62L- and CD11ahigh cells, i.e. primed CD8+ cells. A postexercise suppression of CD4+ cell-count was derived only from CD62L+ cells. The CD11b+ and CD11c+ lymphocytes also increased during exercise, largely attributable to an increase in CD16+ cells which co-expressed CD11b and CD11c molecules. The CD62L surface density of granulocytes increased significantly during recovery. This resulted from a selective influx of CD62Lhigh granulocytes into the circulation. There were no significant changes in per-cell density of the three beta2-integrins on granulocytes and lymphocytes throughout the experimental period. These results suggest that the cell-surface expression of CD62L (and CD11a) molecules is associated with the differential mobilization of CD8+ cells during exercise, the postexercise suppression of CD4+ cell-counts and the granulocytosis following exercise. Verf.-Referat