Recruitment and recirculation of leukocytes after an ultramarathon run: preferential homing of cells expressing high levels of the adhesion molecule LFA-1
Deutscher übersetzter Titel: | Recruitment und Rezirkulation von Leukozyten nach einem Ultramarathonlauf: bevorzugt zur Ruhe kommen solche Zellen mit einer hohen Expression von Adhaesionsmolekuel LFA-1 |
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Autor: | Gabriel, Holger Horst Werner; Brechtel, L.; Urhausen, A.; Kindermann, W. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 15 (1994), Suppl. 3, S. S148-S153, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199503100786 |
Quelle: | BISp |
Abstract des Autors
The alphaLbeta2 (CD11a/CD18) integrin LFA-1 (lymphocyte function-associated antigen-1) mainly contributes to the firm arrest of leucocytes on the endothelium. Its cell surface density is thought to be important for the exercise-induced homing of leucocytes. 9 athletes (7 males, 2 females, age 36-68 years, body mass 64+/-10 kg, height: 175 +/- 10 cm) absolved a competitive 100 km run in 8:07 hours (range: 7:29-9:50 hours). Immunophenotyping of circulating leucocytes and data aquisition by three colour flow cytometry before and up to 3 hours after the race showed that post exercise lymphocyte subpopulations with a higher expression of CD11a like CD3+CD8+CD45RO+ T-cells, natural killer cells CD3-CD16/CD56+) and cytotoxic, not MHC-restricted T-cells (CD3+CD16/CD56+) decreased significantly more than CD45RO+ and CD45RO- helper-T-cells (CD3+CD4+), CD3+CD8+CD45RO- T-cells and B-cells (CD19+), which have lower levels for CD11a. Cell concentrations of regular monocytes (Fc-gamma receptor 3 negative, LFA-1 low positive) increased, whereas mature monocytes (Fc-gamma receptor 3 low or high positive respectively, LFA-1 high positive) decreased. In conclusion the surface density of the adhesion molecule LFA-1 on leucocytes is likely to contribute significantly to the extent of leucocyteïs homing after long endurance exercise. Verf.-Referat