Zum Einfluss des Fettsaeurenprofils und der Vitamin E Konzentration auf die Oxidierbarkeit von LDL Partikeln verschiedener Dichte
| Englischer übersetzter Titel: | Influence of fatty acid profile and vitamin E concentration on the resistance to in vitro oxidation of low density lipoprotein (LDL) particles |
|---|---|
| Autor: | Baumstark, M.W.; Aristequi, R.; König, D.; Frey, I.; Keul, Joseph; Berg, A. |
| Herausgeber: | Liesen, Heinz; Weiß, Michael; Baum, Matthias |
| Erschienen in: | Regulations- und Repairmechanismen : 33. Deutscher Sportärztekongress Paderborn 1993 |
| Veröffentlicht: | Köln: Dt. Ärzte-Verl. (Verlag), 1994, 1994. S. 519-521, Tab., Lit., Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Gedruckte Ressource |
| Sprache: | Deutsch |
| ISBN: | 3769103084 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199504075776 |
| Quelle: | BISp |
Abstract des Autors
In this study, LDL-particles of 16 healthy persons were separated into 6 subfractions by equilibrium density gradient ultracentrifugation. We determined the fatty acid profile by gas liquid chromatography, vitamin E and beta-carotene by HPLC as well as lipids and apolipoprotein B by routine methods. The lag time during Cu++ induced oxidation in vitro served as a measure of the resistance to oxidation. Multivariate analysis demonstrated that the PUFA (poly unsatorated fatty acid) content <%> of LDL is the most important variable in determining the lag time (r = -0.47, r**2 = 0.22, p < 0.0001). The next important factor is the amount of vitamin E per LDL-particle (r**2 = 0.26, for both factors, univariate: r = +0.30). No other variables such as the density of the LDL-subfraction or the beta-carotene concentration contributed significantly to LDL oxidizability in this study. Verf.-Referat