Nedocromil sodium in the prevention of exercise-induced bronchospasm in athletes with asthma
| Deutscher übersetzter Titel: | Nedocromil-Natrium in der Praevention des belastungsinduzierten Asthmas bei sporttreibenden Asthmatikern |
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| Autor: | Todaro, Antonio; Faina, Marcello; Alippi, Bettina; Dal Monte, Antonio; Ruggieri, Filippo |
| Erschienen in: | The Journal of sports medicine and physical fitness |
| Veröffentlicht: | 33 (1993), 2, S. 137-145, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0022-4707, 1827-1928 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199411070002 |
| Quelle: | BISp |
Abstract des Autors
The aim of this study was to determine the efficacy of nedocromil sodium in the prevention of exercise-induced bronchospasm (EIB) in 13 top athletes affected by bronchial asthma. At a dose of 4 mg the drug significantly reduced the fall in FEV1 compared with placebo but not with respect to basal values. In 9 athletes, 4 mg nedocromil sodium produced a good protective effect and reduced the mean fall in FEV1 to 4% with respect to baseline values, while in the remaining 4 subjects, the protective effect was not satisfactory. In these 4 "non responders" 6 mg nedocromil was effective, and in 2 cases induced prolonged bronchodilatation. In conclusion, the effect of nedocromil sodium in the prevention of EIB may be dose dependent in relation to the degree of bronchial hyperreactivity or to interference of other factors. Verf.-Referat