Abstract des Autors

This study reports changes in the coagulation and fibrinolytic tests in a group of 33 untrained healthy subjects before and after a physical exercise, race running over a period of 60 min. For each subject, the parameters of coagulation and fibrinolytic activity are measured in the laboratory: prothrombin time, activated partial prothrombin time, factor VIII and factor VIII-related antigen, fibrinogen, D dimer, fibrinopeptide A (FPA), tissue-type plasminogen activator (t-PA), plasminogen activators (PA) and t-PA inhibitor (PAI). These tests are selected to quantitate the hypothetical fibrinogen consumption in association with physical exercise and the relative role of in vivo activation of the coagulation and fibrinolytic systems. Statistics are presented as mean plus/minus the standard deviation of the mean. The degree of probability of difference between mean values is evaluated using the Students test. The statistically significant results are: 1) no changes of prothrombin time and activated partial prothrombin time; 2) a well-known increase in factor VIII-related antigen. 110.04 to 189.71 after exercise; 3) no change in the concentration of fibrinogen and D dimer; 4) no significant increase in the concentration of fibrinopeptide A, 2.73 ng/ml to 5.78 ng/ml after exercise for 18 subjects; 5) significant increases of tissue-type plasminogen activator, 3.75 ng/ml to 12.77 ng/ml and plasminogen activators, 0.58 UI/ml to 0.86 UI/ml following the exercise; 6) no changes of t-PA inhibitor; 7) there is no positive correlation between t-PA inhibitor level and the t-PA antigen concentration in plasma. The results suggest fibrinogenolyis rather than fibrinolysis from the endothelial cells, without real hypercoagulable state; but, the significance of the changes in the fibrinolytic system induced by physical exercise remains to be established. Therefore, exercise may have a favorable effect in preventing thrombosis. Verf.-Referat