Effect of marihuana on cardiorespiratory response to submaximal exercise
| Deutscher übersetzter Titel: | Wirkung von Marihuana auf Herz-Kreislaufreaktionen auf maximale Belastung |
|---|---|
| Autor: | Avakian, Edward V.; Horvath, Steven M.; Michael, Ernest D.; Jacobs, Samuel |
| Erschienen in: | Clinical pharmacology and therapeutics |
| Veröffentlicht: | 26 (1979), 6, S. 777-781, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0260-0099 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU198202015655 |
| Quelle: | BISp |
Abstract
Six male chronic marihuana (MH) users exercised on a bicycle ergometer for 15 min at 50 VO2max under 3 conditions: (1) not smoking (control), (2) after smoking MH containing 7,5 mg (-) delta-9-tetrahydrocannabinol, and (3) after smoking placebo marihuana (PL). The MH was administered double-blind in a counter-balanced repeated-measures design. Heart rates (HRs), arterial blood pressures (BPs), pulmonary ventilation (VE), and oxygen uptake (VO2) were measured during exercise and 15 min recovery. PL had no effect on any of the physiologic variables. Smoking MH had no effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), VE, or VO2, but did induce a marked increase in heart rate which persisted throughout exercise and recovery periods, averaging 34 higher than control values at rest, 18 higher during exercise, and up to 50 higher during recovery. MH smoking increased the product of HR x SBP in all circumstances. Verf.-Referat