Consumption of a high-fat-high-sucrose diet partly diminishes mechanical and structural adaptations of cardiac muscle following resistance training
Autor: | Boldt, Kevin; Mattiello, Stela; Joumaa, Venus; Turnbull, Jeannine; Fedak, Paul W.M.; Herzog, Walter |
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Sprache: | Englisch |
Veröffentlicht: |
2021 |
Quelle: | PubMed Central (PMC) |
Online Zugang: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342188/ http://www.ncbi.nlm.nih.gov/pubmed/34315201 http://dx.doi.org/10.20463/pan.2021.0009 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342188/ https://doi.org/10.20463/pan.2021.0009 |
Erfassungsnummer: | ftpubmed:oai:pubmedcentral.nih.gov:8342188 |
Zusammenfassung
[PURPOSE]: The purpose of this study was to investigate the effects of a high-fat high-sucrose (HFHS) diet on previously reported adaptations of cardiac morphological and contractile properties to resistance training. [METHODS]: Twelve-week-old rats participated in 12-weeks of resistance exercise training and consumed an HFHS diet. Echocardiography and skinned cardiac muscle fiber bundle testing were performed to determine the structural and mechanical adaptations. [RESULTS]: Compared to chow-fed sedentary animals, both HFHS- and chow-fed resistance-trained animals had thicker left ventricular walls. Isolated trabecular fiber bundles from chow-fed resistance-trained animals had greater force output, shortening velocities, and calcium sensitivities than those of chow-fed sedentary controls. However, trabeculae from the HFHS resistance-trained animals had greater force output but no change in unloaded shortening velocity or calcium sensitivity than those of the chow-fed sedentary group animals. [CONCLUSION]: Resistance exercise training led to positive structural and mechanical adaptations of the heart, which were partly offset by the HFHS diet.