TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise
| Autor: | Huang, Xing; Hu, Yanxin; Zhao, Li; Gu, Boya; Zhu, Rongxin; Li, Yan; Yang, Yun; Han, Tianyu; Yu, Jiabei; Mu, Lianwei; Han, Peng; Li, Cui; Zhang, Weijia; Hu, Yang |
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| Sprache: | Englisch |
| Veröffentlicht: |
2019 |
| Quelle: | PubMed Central (PMC) |
| Online Zugang: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734159/ http://dx.doi.org/10.1016/j.sjbs.2019.06.001 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734159/ https://doi.org/10.1016/j.sjbs.2019.06.001 |
| Erfassungsnummer: | ftpubmed:oai:pubmedcentral.nih.gov:6734159 |
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ftpubmed:oai:pubmedcentral.nih.gov:6734159 |
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base |
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bispbase |
| url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734159/ http://dx.doi.org/10.1016/j.sjbs.2019.06.001 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734159/ https://doi.org/10.1016/j.sjbs.2019.06.001 |
| url-type |
primary primary pmc info |
| publishDate |
2019 |
| publishDate_facet |
2019 |
| baseCollectionName |
PubMed Central (PMC) |
| baseCountry |
us |
| title |
TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise |
| spellingShingle |
TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise |
| title_short |
TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise |
| title_sort |
TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise |
| spelling |
TRPV4 plays an important role in rat prefrontal cortex changes induced by acute hypoxic exercise |
| author2 |
Huang, Xing Hu, Yanxin Zhao, Li Gu, Boya Zhu, Rongxin Li, Yan Yang, Yun Han, Tianyu Yu, Jiabei Mu, Lianwei Han, Peng Li, Cui Zhang, Weijia Hu, Yang |
| author_facet |
Huang, Xing Hu, Yanxin Zhao, Li Gu, Boya Zhu, Rongxin Li, Yan Yang, Yun Han, Tianyu Yu, Jiabei Mu, Lianwei Han, Peng Li, Cui Zhang, Weijia Hu, Yang |
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Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor |
| abstract |
OBJECTIVE: This study aims to investigate the effects of TRPV4 on acute hypoxic exercise-induced central fatigue, in order to explore the mechanism in central for exercise capacity decline of athletes in the early stage of altitude training. METHODS: 120 male Wistar rats were randomly divided into 12 groups: 4 normoxia groups (quiet group, 5-level group, 8-level group, exhausted group), 4 groups at simulated 2500 m altitude (grouping as before), 4 groups at simulated 4500 m altitude (grouping as before), 10 in each group. With incremental load movement, materials were drawn corresponding to the load. Intracellular calcium ion concentration was measured by HE staining, enzyme-linked immunosorbent assay, immunohistochemistry, RT-qPCR, Fluo-4/AM and Fura-2/AM fluorescence staining. RESULTS: (1) Hypoxic 2–5 groups showed obvious venous congestion, with symptoms similar to normoxia-8 group; Hypoxic 2–8 groups showed meningeal loosening edema, infra-meningeal venous congestion, with symptoms similar to normoxia-exhausted group and hypoxic 1-exhaused group. (2) For 5,6-EET, regardless of normoxic or hypoxic environment, significant or very significant differences existed between each exercise load group (normoxic − 5 level 20.58 ± 0.66 pg/mL, normoxic − 8 level 23.15 ± 0.46 pg/mL, normoxic - exhausted 26.66 ± 0.71 pg/mL; hypoxic1-5 level 21.72 ± 0.43 pg/mL, hypoxic1-8 level 24.73 ± 0.69 pg/mL, hypoxic 1-exhausted 28.68 ± 0.48 pg/mL; hypoxic2-5 level 22.75 ± 0.20 pg/mL, hypoxic2-8 level 25.62 ± 0.39 pg/mL, hypoxic 2-exhausted 31.03 ± 0.41 pg/mL) and quiet group in the same environment(normoxic-quiet 18.12 ± 0.65 pg/mL, hypoxic 1-quiet 19.94 ± 0.43 pg/mL, hypoxic 2-quiet 21.72 ± 0.50 pg/mL). The 5,6-EET level was significantly or extremely significantly increased in hypoxic 1 environment and hypoxic 2 environment compared with normoxic environment under the same load. (3) With the increase of exercise load, expression of TRPV4 in the rat prefrontal cortex was significantly increased; hypoxic exercise groups showed ... |
| abstract_type |
general |
| abstract_lang |
eng |
| language |
eng |
| publisher |
Elsevier |
| _version_ |
1793496224146391040 |
| score |
13,558404 |