The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study

Author: Yan-Chuan Li; Ying Li; Li-Yan Liu; Yang Chen; Tian-Qi Zi; Shan-Shan Du; Yong-Shuai Jiang; Ren-Nan Feng; Chang-Hao Sun
Language: English
Published: 2015
Source: Directory of Open Access Journals: DOAJ Articles
Online Access: http://www.mdpi.com/2072-6643/7/11/5486
https://doaj.org/toc/2072-6643
https://doi.org/10.3390/nu7115486
https://doaj.org/article/f623c8d19a4f4410b427193d5cdd89a8
Identification number: ftdoajarticles:oai:doaj.org/article:f623c8d19a4f4410b427193d5cdd89a8

Summary

This study aims to examine the association between the ratio of dietary branched chain amino acids (BCAA) and risk of obesity among young northern Chinese adults. A total of 948 randomly recruited participants were asked to finish our internet-based dietary questionnaire for the Chinese (IDQC). Associations between dietary BCAA ratio and prevalence of overweight/obesity and abdominal obesity were analyzed. Furthermore, 90 subjects were randomly selected to explore the possible mechanism. Dietary BCAA ratio in obese participants was significantly lower than non-obese participants. We found negative correlations between the ratio of dietary BCAA and body mass index (BMI) (r = −0.197, p < 0.001) or waist circumference (r = −0.187, p < 0.001). Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartiles of dietary BCAA ratio for overweight/obesity were 0.508 (0.265–0.972) and 0.389 (0.193–0.783), respectively (all p < 0.05). After stratification by gender, the significance still existed in the 3rd and 4th quartile in males and the 4th quartile in females. For abdominal obesity, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartile of dietary BCAA ratio were 0.351 (0.145–0.845) and 0.376 (0.161–0.876), respectively (all p < 0.05). This significance was stronger in males. Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation. In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.