Effect of 12-Week Low-intensity Exercise on Interleukin-2, Interferon-gamma, and Interleukin-4 Cytokine Production in Rat Spleens
Autor: | Eun-Ju Choi; Wi-Young So |
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Sprache: | Englisch |
Veröffentlicht: |
2018 |
Quelle: | Directory of Open Access Journals: DOAJ Articles |
Online Zugang: |
http://www.jomh.org/index.php/JMH/article/view/62 https://doaj.org/toc/1875-6859 doi:10.22374/1875-6859.14.3.1 1875-6859 https://doaj.org/article/d34bbed19e7f413ebdf0eba2f1b92f8c https://doi.org/10.22374/1875-6859.14.3.1 https://doaj.org/article/d34bbed19e7f413ebdf0eba2f1b92f8c |
Erfassungsnummer: | ftdoajarticles:oai:doaj.org/article:d34bbed19e7f413ebdf0eba2f1b92f8c |
Zusammenfassung
Background and Objective: High-intensity exercise has been linked to immunity; however, the relationship between low-intensity exercise and the immune system is unclear. In this study, the effects of exercise on cytokine production in T helper 1 (interleukin-2 [IL-2] and interferon-gamma [INF-g]) and T helper 2 cells (interleukin-4 [IL-4]) in spleens were investigated. Material and Methods: Sprague–Dawley male rats were divided into a control group (CON, n = 10) and a low-intensity exercise group (EX, n = 10). EX rats were trained on a treadmill (8 m/min, 50 min/day, 5 times over 12 weeks). Spleen tissues were analyzed by hematoxylin-eosin staining and real-time PCR to quantify IL-4, INF-g, and IL-2 expression. Results: IL-4 expression was significantly higher in the EX group than in the CON group (p < 0.05). However, IL-2 and INF-g expression did not differ between groups (p > 0.05). Conclusion: These results suggest that exercise in rats enhances immune function by regulating cytokine production in T helper type 2 (IL-4) cells, but not in T helper type 1 (IL-2 and IFN-g) cells of the activated spleen.