Role of Ca2+ signaling in skeletal muscle hypertrophy and atrophy
| Autor: | Naoki Ito; Shin’ichi Takeda |
|---|---|
| Sprache: | Englisch |
| Veröffentlicht: |
2015 |
| Quelle: | Directory of Open Access Journals: DOAJ Articles |
| Online Zugang: |
https://www.jstage.jst.go.jp/article/jpfsm/4/2/4_171/_pdf/-char/en https://doaj.org/toc/2186-8131 https://doaj.org/toc/2186-8123 2186-8131 2186-8123 doi:10.7600/jpfsm.4.171 https://doaj.org/article/58c7e3986d724c1495eee54330e3a783 https://doi.org/10.7600/jpfsm.4.171 https://doaj.org/article/58c7e3986d724c1495eee54330e3a783 |
| Erfassungsnummer: | ftdoajarticles:oai:doaj.org/article:58c7e3986d724c1495eee54330e3a783 |
Zusammenfassung
Skeletal muscle maintains an adequate volume that is commensurate with its surrounding environment. Although intracellular signaling molecules and pathways underlying the regulation of protein synthesis/degradation and subsequent muscle hypertrophy/atrophy are well studied, upstream regulators are largely unknown. In this review, we summarize the recent advances relating to the role of Ca2+ signaling as an upstream regulator of intracellular signaling pathways that regulate muscle plasticity, suggesting a new therapeutic target to control muscle mass.