A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma
| Autor: | Rafal Kaminski; Krzysztof Kulinski; Katarzyna Kozar-Kaminska; Monika Wielgus; Maciej Langner; Marcin K. Wasko; Jacek Kowalczewski; Stanislaw Pomianowski |
|---|---|
| Sprache: | Englisch |
| Veröffentlicht: |
2018 |
| Quelle: | Directory of Open Access Journals: DOAJ Articles |
| Online Zugang: |
http://dx.doi.org/10.1155/2018/9315815 https://doaj.org/toc/2314-6133 https://doaj.org/toc/2314-6141 2314-6133 2314-6141 doi:10.1155/2018/9315815 https://doaj.org/article/4b9610ca65a94bbcac7d154211414c90 https://doi.org/10.1155/2018/9315815 https://doaj.org/article/4b9610ca65a94bbcac7d154211414c90 |
| Erfassungsnummer: | ftdoajarticles:oai:doaj.org/article:4b9610ca65a94bbcac7d154211414c90 |
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ftdoajarticles:oai:doaj.org/article:4b9610ca65a94bbcac7d154211414c90 |
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http://dx.doi.org/10.1155/2018/9315815 https://doaj.org/toc/2314-6133 https://doaj.org/toc/2314-6141 2314-6133 2314-6141 doi:10.1155/2018/9315815 https://doaj.org/article/4b9610ca65a94bbcac7d154211414c90 https://doi.org/10.1155/2018/9315815 https://doaj.org/article/4b9610ca65a94bbcac7d154211414c90 |
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primary primary primary primary primary primary primary info info |
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Medicine R A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma |
| publishDate |
2018 |
| publishDate_facet |
2018 |
| baseCollectionName |
Directory of Open Access Journals: DOAJ Articles |
| baseCountry |
org |
| title |
A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma |
| spellingShingle |
A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma |
| title_short |
A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma |
| title_sort |
A Prospective, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating Meniscal Healing, Clinical Outcomes, and Safety in Patients Undergoing Meniscal Repair of Unstable, Complete Vertical Meniscal Tears (Bucket Handle) Augmented with Platelet-Rich Plasma |
| author2 |
Rafal Kaminski Krzysztof Kulinski Katarzyna Kozar-Kaminska Monika Wielgus Maciej Langner Marcin K. Wasko Jacek Kowalczewski Stanislaw Pomianowski |
| author_facet |
Rafal Kaminski Krzysztof Kulinski Katarzyna Kozar-Kaminska Monika Wielgus Maciej Langner Marcin K. Wasko Jacek Kowalczewski Stanislaw Pomianowski |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor Autor |
| abstract |
Objective. The present study aimed to investigate the effectiveness and safety of platelet-rich plasma (PRP) application in arthroscopic repair of complete vertical tear of meniscus located in the red-white zone. Methods. This single center, prospective, randomized, double-blind, placebo-controlled, parallel-arm study included 37 patients with complete vertical meniscus tears. Patients received an intrarepair site injection of either PRP or sterile 0.9% saline during an index arthroscopy. The primary endpoint was the rate of meniscus healing in the two groups. The secondary endpoints were changes in the International Knee Documentation Committee (IKDC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and analog scale (VAS) in the two groups at 42 months. Results. After 18 weeks, the meniscus healing rate was significantly higher in the PRP-treated group than in the control group (85% versus 47%, P=0.048). Functional outcomes were significantly better 42 months after treatment than at baseline in both groups. The IKDC score, WOMAC, and KOOS were significantly better in the PRP-treated group than in the control group. No adverse events were reported during the study period. Conclusions. The findings of this study indicate that PRP augmentation in meniscus repair results in improvements in both meniscus healing and functional outcome. |
| abstract_type |
general |
| abstract_lang |
eng |
| language |
eng |
| publisher |
Hindawi Limited |
| _version_ |
1793496395984928768 |
| score |
13,561486 |