Effect of Short Term Intensive Lifestyle Intervention on Hepatic Steatosis Indexes in Adults with Obesity and/or Type 2 Diabetes

Author: Elisa Reginato; Roberto Pippi; Cristina Aiello; Emilia Sbroma Tomaro; Claudia Ranucci; Livia Buratta; Vittorio Bini; Giulio Marchesini; Pierpaolo De Feo; Carmine Fanelli
Language: English
Published: 2019
Source: Directory of Open Access Journals: DOAJ Articles
Online Access: https://www.mdpi.com/2077-0383/8/6/851
Identification number: ftdoajarticles:oai:doaj.org/article:32c5b31130b148d08af1cd2d038b557d


Background: Non-alcoholic fatty liver disease (NAFLD) has an estimated prevalence of 20−30% in the general population and even higher in individuals with metabolic risk factors. The aim of this study was to evaluate the effect of a lifestyle intervention program on surrogate markers of hepatic steatosis in obesity and/or type 2 diabetes patients, enrolled in the C.U.R.I.A.Mo. (Centro Universitario di Ricerca Interdipartimentale Attività Motoria) trial. Methods: 102 subjects (56 females and 46 males, aged between 23 and 78) with type 2 diabetes, obesity or a BMI of at least 25 kg/m 2 with comorbidities, participated in the intensive phase of a multidisciplinary lifestyle intervention program at the Healthy Lifestyle Institute of the University of Perugia (C.U.R.I.A.Mo.). Six indices related to NAFLD (Visceral Adiposity Index, Fatty Liver index, Non-Alcoholic Fatty Liver Disease liver fat score and liver fat equation, hepatic steatosis index and TyG index) were calculated before and after a three-month multidisciplinary lifestyle intervention. Results: The intervention improved the anthropometric and clinical parameters in the total population, the obese and/or diabetics. Data showed a significant weight loss, a reduced waist circumference, triglycerides, and an improvement in Mediterranean diet adherence. Hepatic steatosis indices were significantly reduced in the total population and in different subgroups (males, females, obesity and diabetes).