Effect of preoperative pregabalin on postoperative pain after gastrectomy

Autor: Chan Yoon Park; Sol Hee Park; Dong Gun Lim; Eun Kyung Choi
Sprache: Englisch; Koreanisch
Veröffentlicht: 2018
Quelle: Directory of Open Access Journals: DOAJ Articles
Online Zugang: http://yujm.yu.ac.kr/upload/pdf/yujm-35-40.pdf
https://doaj.org/toc/2384-0293
2384-0293
doi:10.12701/yujm.2018.35.1.40
https://doaj.org/article/2e7c75de944a4266b365f45c778bd9cd
https://doi.org/10.12701/yujm.2018.35.1.40
https://doaj.org/article/2e7c75de944a4266b365f45c778bd9cd
Erfassungsnummer: ftdoajarticles:oai:doaj.org/article:2e7c75de944a4266b365f45c778bd9cd

Zusammenfassung

Background Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain. Methods Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period. Results The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth. Conclusion A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.