Matrix metalloproteinase-9 as an independent predictor of recurrence after catheter ablation of atrial fibrillation
Autor: | A. V. Goryachiy; A. I. Gozhenko; E. M. Levchenko; V. V. Goriachyi; M. A. Kuznetsova; M. I. Arapu |
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Sprache: | Englisch; Spanisch; Polnisch; Russisch; Ukrainisch |
Veröffentlicht: |
2017 |
Quelle: | Directory of Open Access Journals: DOAJ Articles |
Online Zugang: |
http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6231 https://doaj.org/toc/2391-8306 2391-8306 doi:10.5281/zenodo.1472854 https://doaj.org/article/0596c199e60f486fac44cc515e7b66f1 https://doi.org/10.5281/zenodo.1472854 https://doaj.org/article/0596c199e60f486fac44cc515e7b66f1 |
Erfassungsnummer: | ftdoajarticles:oai:doaj.org/article:0596c199e60f486fac44cc515e7b66f1 |
Zusammenfassung
Objectives: In this study, the serum level of matrix metalloproteinase-9 was studied as an independent predictor of recurrence after catheter ablation of a persistent form of atrial fibrillation. Methods: The study included 46 patients with a persistent form of atrial fibrillation. In all patients, serum level of matrix metalloproteinase-9 was measured before the procedure of catheter radiofrequency ablation and its association with recurrence of arrhythmia at the end of the postoperative period was estimated. Results: The follow-up period was 12.3+ for 6.4 months, in 16 (34.7%) patients there was a relapse of arrhythmia after the procedure of catheter radiofrequency ablation. The baseline level of matrix metalloproteinase-9 was higher in patients with relapsed arrhythmia (297.73 + 81.28 and 234.41 + 93.36 ng / ml, respectively, p=0.006). Multivariate analysis showed that parameters such as the level of matrix metalloproteinase-9, the history of atrial fibrillation and the diameter of the left atrium were independent predictors of arrhythmia recurrence. Conclusion: The serum level of matrix metalloproteinase-9 is an independent predictor of arrhythmia recurrence after performing the procedure of catheter radiofrequency ablation in patients with persistent form of atrial fibrillation.