A brain-machine-muscle interface for restoring hindlimb locomotion after complete spinal transection in rats.

Author: Monzurul Alam; Xi Chen; Zicong Zhang; Yan Li; Jufang He
Language: English
Published: 2014
Source: Directory of Open Access Journals: DOAJ Articles
Online Access: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25084446/?tool=EBI
https://doaj.org/toc/1932-6203
1932-6203
doi:10.1371/journal.pone.0103764
https://doaj.org/article/04b1b5414d0044fbad5e87274d47b148
https://doi.org/10.1371/journal.pone.0103764
https://doaj.org/article/04b1b5414d0044fbad5e87274d47b148
Identification number: ftdoajarticles:oai:doaj.org/article:04b1b5414d0044fbad5e87274d47b148

Summary

A brain-machine interface (BMI) is a neuroprosthetic device that can restore motor function of individuals with paralysis. Although the feasibility of BMI control of upper-limb neuroprostheses has been demonstrated, a BMI for the restoration of lower-limb motor functions has not yet been developed. The objective of this study was to determine if gait-related information can be captured from neural activity recorded from the primary motor cortex of rats, and if this neural information can be used to stimulate paralysed hindlimb muscles after complete spinal cord transection. Neural activity was recorded from the hindlimb area of the primary motor cortex of six female Sprague Dawley rats during treadmill locomotion before and after mid-thoracic transection. Before spinal transection there was a strong association between neural activity and the step cycle. This association decreased after spinal transection. However, the locomotive state (standing vs. walking) could still be successfully decoded from neural recordings made after spinal transection. A novel BMI device was developed that processed this neural information in real-time and used it to control electrical stimulation of paralysed hindlimb muscles. This system was able to elicit hindlimb muscle contractions that mimicked forelimb stepping. We propose this lower-limb BMI as a future neuroprosthesis for human paraplegics.