Exploring the effects of six weeks of resistance training on the fecal microbiome of older adult males : secondary analysis of a peanut protein supplemented randomized controlled trial
Deutscher übersetzter Titel: | Untersuchung der Effekte eines sechswöchigen Krafttrainings auf das Fäkalmikrobiom älterer Männer : Sekundäranalyse einer randomisierten kontrollierten Studie zu Erdnussprotein-Supplementierung |
---|---|
Autor: | Moore, Johnathon H.; Smith, Kristen S.; Chen, Dongquan; Lamb, Donald A.; Smith, Morgan A.; Osburn, Shelby C.; Ruple, Bradley A.; Morrow, Casey D.; Huggins, Kevin W.; McDonald, James R.; Brown, Michael D.; Young, Kaelin C.; Roberts, Michael D.; Frugé, Andrew D. |
Erschienen in: | Sports |
Veröffentlicht: | 10 (2022), 5, Art.-ID 65, [15 S.], Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 2075-4663 |
DOI: | 10.3390/sports10050065 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU202208005846 |
Quelle: | BISp |
Abstract des Autors
The bacteria inhabiting the gastrointestinal tract contribute to numerous host functions and can be altered by lifestyle factors. We aimed to determine whether a 6-week training intervention altered fecal microbiome diversity and/or function in older males. Fecal samples were collected prior to and following a 6-week twice-weekly supervised resistance training intervention in 14 older Caucasian males (65 ± 10 years, 28.5 ± 3.2 kg/m2) with minimal prior training experience. Participants were randomized to receive a daily defatted peanut powder supplement providing 30 g protein (n = 8) or no supplement (n = 6) during the intervention. Bacterial DNA was isolated from pre-and post-training fecal samples, and taxa were identified using sequencing to amplify the variable region 4 (V4) of the 16S ribosomal RNA gene. Training significantly increased whole-body and lower-body lean mass (determined by dual energy X-ray absorptiometry) as well as leg extensor strength (p < 0.05) with no differences between intervention groups. Overall composition of the microbiome and a priori selected taxa were not significantly altered with training. However, MetaCYC pathway analysis indicated that metabolic capacity of the microbiome to produce mucin increased (p = 0.047); the tight junction protein, zonulin, was measured in serum and non-significantly decreased after training (p = 0.062). Our data suggest that resistance training may improve intestinal barrier integrity in older Caucasian males; further investigation is warranted.