Chronic exposure to low-dose carbon monoxide alters hemoglobin mass and V' O2max
Deutscher übersetzter Titel: | Niedrig dosiertem Kohlenmonoxid chronisch ausgesetzt zu sein verändert die Hämoglobinmasse und maximale Sauerstoffaufnahme |
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Autor: | Schmidt, Walter Franz-Joachim; Hoffmeister, Torben; Haupt, Sandra; Schwenke, Dirk; Wachsmuth, Nadine Bianca; Byrnes, William C. |
Erschienen in: | Medicine and science in sports and exercise |
Veröffentlicht: | 52 (2020), 9, S. 1879-1887, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0195-9131, 1530-0315 |
DOI: | 10.1249/MSS.0000000000000420 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU202103001755 |
Quelle: | BISp |
Abstract des Autors
By blocking the oxygen binding sites on the hemoglobin molecule, chronic low-dose carbon monoxide (CO) administration may produce similar effects to those of exposure to altitude.
Purpose: This study aimed to determine the effect of chronic low-dose CO application on hemoglobin mass (Hbmass) and V˙O2max.
Methods: For 3 wk, 11 healthy and moderately trained male subjects inhaled a CO bolus five times per day to increase their HbCO concentration by ~5%. Another 11 subjects received a placebo. Hbmass, serum erythropoietin concentration, ferritin, and basic hematological parameters were determined before and weekly during and until 3 wk after the CO inhalation period. V˙O2max tests on a cycle ergometer were performed before and after the CO administration period.
Results: In the CO group, Hbmass increased from 919 ± 69 to 962 ± 78 g in week 3 (P < 0.001) and was maintained for the following 3 wk. Reticulocytes (%) and immature reticulocyte fraction significantly increased after 1 wk. Serum erythropoietin concentration tended to increase after 1 wk (P = 0.07) and was suppressed in the postperiod (P < 0.01). Ferritin decreased during the inhalation period (from 106 ± 37 to 72 ± 37 ng·mL, P < 0.001). V˙O2max tended to increase from 4230 ± 280 to 4350 ± 350 mL·min (P < 0.1) immediately after the inhalation period and showed a significant relationship to the change in Hbmass (y = 4.1x - 73.4, r = 0.70, P < 0.001).
Conclusions: Chronic continuous exposure to low-dose CO enhances erythropoietic processes resulting in a 4.8% increase in Hbmass. The individual changes in Hbmass were correlated to the corresponding changes in V˙O2max. Examination of ethical and safety concerns is warranted before the implementation of low-dose CO inhalation in the clinical/athletic setting as a tool for modifying Hbmass.