In vitro Metabolismus synthetischer Cannabinoide und deren Nachweis in vivo
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| Autor: | Gaunitz, Franziska |
|---|---|
| Gutachter: | Thevis, Mario; Andresen-Streichert, Hilke |
| Veröffentlicht: | Köln: 2020, XV, 78 S., Lit. |
| Forschungseinrichtung: | Deutsche Sporthochschule Köln / Institut für Biochemie |
| Hochschulschriftenvermerk: | Köln, Dt. Sporthochsch., Diss., 2020 (Kumulativ) |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Monografie |
| Medienart: | Gedruckte Ressource |
| Dokumententyp: | Hochschulschrift Dissertation Graue Literatur |
| Sprache: | Deutsch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU202010008879 |
| Quelle: | BISp |
Abstract des Autors
The detection of synthetic cannabinoid abuse via urine screenings requires knowledge of their metabolism, major metabolites and urinary targets, recommendable and suitable for implementation in an existing LC-MS/MS method. The targets identified within this dissertation were implemented as part of a routine screening LC-ESI-MS/MS method for urinary synthetic cannabinoid metabolites, having been developed and published in parallel to this dissertation.
The first article covers the in vitro and in vivo phase I-metabolism investigations of THJ-018 and THJ-2201 by pHLM and CYP incubations, and urine screening, using extractive workup (SPE) and LC-HRMS.
The second article comprises the phase I-metabolism of the synthetic cannabinoids EG-018 and EG-2201.
The third article deals not only with the results of systematic toxicology analysis of post-mortem samples taken from a case of a 27-year-old man, but also with the examination of MDMB-CHMICA and its metabolites. (geändert)