microRNAs in high and low responders to resistance training in breast cancer survivors
Gespeichert in:
| Deutscher übersetzter Titel: | microRNAs bei High- und Low-Respondern auf Krafttraining unter Brustkrebspatientinnen |
|---|---|
| Autor: | Hagstrom, Amanda D.; Denham, Joshua |
| Erschienen in: | International journal of sports medicine |
| Veröffentlicht: | 39 (2018), 6, S. 482-489, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0172-4622, 1439-3964 |
| DOI: | 10.1055/a-0592-7691 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201807005335 |
| Quelle: | BISp |
| id |
PU201807005335 |
|---|---|
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db |
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Literatur |
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2018-08-02T15:16:57Z |
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2018-07-28T14:18:13Z |
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BISp |
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Zeitschriftenartikel |
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JO00000000664 |
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JOI201800060000664 |
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International journal of sports medicine |
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International journal of sports medicine, 2018, 6 |
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PU201807005335 |
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microRNAs in high and low responders to resistance training in breast cancer survivors |
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0482 |
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bisparticle |
| publishDate |
2018 |
| publishDate_facet |
2018 |
| language |
eng |
| title |
microRNAs in high and low responders to resistance training in breast cancer survivors |
| spellingShingle |
microRNAs in high and low responders to resistance training in breast cancer survivors Krafttraining Krebserkrankung Molekularbiologie Muskelkraft Muskelphysiologie Onkologie Sportmedizin Sporttherapie Untersuchung, empirische |
| title_sort |
micrornas in high and low responders to resistance training in breast cancer survivors |
| title_short |
microRNAs in high and low responders to resistance training in breast cancer survivors |
| title_alt |
microRNAs bei High- und Low-Respondern auf Krafttraining unter Brustkrebspatientinnen |
| title_alt_lang |
deu |
| media_type |
Elektronische Ressource (online) Gedruckte Ressource |
| city |
Stuttgart |
| abstract |
Accounting for one in three cancer diagnoses, breast cancer is the second most commonly diagnosed cancer in women. Exercise has a well-accepted role in the multi-disciplinary approach to rehabilitating breast cancer survivors. Despite the many known benefits of resistance training on women recovering from breast cancer, the molecular mechanisms are poorly understood. MicroRNAs are small non-coding RNAs that have crucial roles in growth and development. Here, we analysed the abundance of 9 miRNAs, with known roles in muscle physiology and some linked to cancer, in serum samples from 24 breast cancer survivors before and after a 16-week resistance training or usual care intervention. The resistance training group completed supervised thrice-weekly training. miRNA abundance was assessed before and after the intervention period using qPCR. There were no statistically significant changes in any of the miRNAs between groups after the intervention period (all p>0.05). After assessing miRNA abundance in context with high and low responders to resistance training, we observed that relative to low responders, high responders exhibited increased miR-133a-3p and a borderline statistically significant increase in miR-370-3p. Findings from our controlled study indicate the diverse interindividual miRNA responses to resistance training and reveal a discordant regulation between high and low responders. |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Hagstrom, Amanda D. Denham, Joshua |
| author_facet |
Hagstrom, Amanda D. Denham, Joshua |
| author2-role |
Autor Autor |
| author2-authorityid |
P364873 |
| author_author_facet |
Hagstrom, Amanda D. Denham, Joshua |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Hagstrom, Amanda D./ 0/Autor/ 1/Autor/Denham, Joshua/ |
| doi |
10.1055/a-0592-7691 |
| spelling |
10.1055/a-0592-7691 0172-4622 1439-3964 IJSMD 603122-5 Krafttraining Krebserkrankung Molekularbiologie Muskelkraft Muskelphysiologie Onkologie Sportmedizin Sporttherapie Untersuchung, empirische carcinosis empirical investigation molecular biology muscle physiology muscle strength oncology sports medicine sport therapy strength training Empirie Empirismus Untersuchung, experimentelle Untersuchung Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Kräftigung Kraftschulung Muskelkrafttraining Krafttraining, spezielles Muskelkräftigung Kraft Therapiesport Übungstherapie Physiologie Genbiologie empirical study cancer neoplasm resistance training muscle force exercise therapy microRNAs in high and low responders to resistance training in breast cancer survivors PU201807005335 201807005335 |
| url |
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0592-7691 https://dx.doi.org/10.1055/a-0592-7691 |
| url-type |
fulltext fulltext |
| url-free |
0 0 |
| issn |
0172-4622 1439-3964 |
| coden |
IJSMD |
| zdb |
603122-5 |
| location_hierarchy_facet |
0/Deutschland/ 1/Deutschland/Baden-Württemberg/ 0/Deutschland/ 1/Deutschland/Baden-Württemberg/ |
| topic |
Krafttraining Krebserkrankung Molekularbiologie Muskelkraft Muskelphysiologie Onkologie Sportmedizin Sporttherapie Untersuchung, empirische |
| topic_facet |
Krafttraining Krebserkrankung Molekularbiologie Muskelkraft Muskelphysiologie Onkologie Sportmedizin Sporttherapie Untersuchung, empirische |
| topic_en |
carcinosis empirical investigation molecular biology muscle physiology muscle strength oncology sports medicine sport therapy strength training |
| topic_en_facet |
carcinosis empirical investigation molecular biology muscle physiology muscle strength oncology sports medicine sport therapy strength training |
| synonym |
Empirie Empirismus Untersuchung, experimentelle Untersuchung Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Kräftigung Kraftschulung Muskelkrafttraining Krafttraining, spezielles Muskelkräftigung Kraft Therapiesport Übungstherapie Physiologie Genbiologie |
| synonym_en |
empirical study cancer neoplasm resistance training muscle force exercise therapy |
| journal_facet |
International journal of sports medicine |
| container_title |
International journal of sports medicine |
| container_volume |
39 |
| container_issue |
6 |
| container_start_page |
S. 482-489 |
| has_references |
1 |
| institution |
BISp |
| journal_fac |
JO00000000664 |
| journal_year |
2018 |
| journal_issue |
6 |
| _version_ |
1791510107620638720 |
| score |
13,560151 |