Concomitant external pneumatic compression treatment with consecutive days of high intensity interval training reduces markers of proteolysis
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| Deutscher übersetzter Titel: | Die gleichzeitige externe pneumatische Kompressionsbehandlung mit aufeinanderfolgenden Tagen mit hochintensivem Intervalltraining reduziert die Proteolyse-Marker |
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| Autor: | Haun, Cody T.; Roberts, Michael D.; Romero, Matthew A.; Osburn, Shelby C.; Healy, James C.; Moore, Angelique N.; Mobley, Christopher B.; Roberson, Paul A.; Kephart, Wesley C.; Mumford, Petey W.; Goodlett, Michael D.; Pascoe, David D.; Martin, Jeffrey S. |
| Erschienen in: | European journal of applied physiology |
| Veröffentlicht: | 117 (2017), 12, S. 2587–2600, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 1439-6319, 0301-5548 |
| DOI: | 10.1007/s00421-017-3746-2 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201807005131 |
| Quelle: | BISp |
Abstract des Autors
Purpose: To compare the effects of external pneumatic compression (EPC) and sham when used concurrently with high intensity interval training (HIIT) on performance-related outcomes and recovery-related molecular measures.
Methods: Eighteen recreationally endurance-trained male participants (age: 21.6 +/- 2.4 years, BMI: 25.7 +/- 0.5 kg/m2, VO2peak: 51.3 +/- 0.9 mL/kg/min) were randomized to balanced sham and EPC treatment groups. Three consecutive days of HIIT followed by EPC/sham treatment (Days 2–4) and 3 consecutive days of recovery (Days 5–7) with EPC/sham only on Days 5–6 were employed. Venipuncture, flexibility and pressure-to-pain threshold (PPT) measurements were made throughout. Vastus lateralis muscle was biopsied at PRE (i.e., Day 1), 1-h post-EPC/sham treatment on Day 2 (POST1), and 24-h post-EPC/sham treatment on Day 7 (POST2). 6-km run time trial performance was tested at PRE and POST2.
Results: No group × time interaction was observed for flexibility, PPT, or serum measures of creatine kinase (CK), hsCRP, and 8-isoprostane. However, there was a main effect of time for serum CK (p = 0.005). Change from PRE in 6-km run times at POST2 were not significantly different between groups. Significant between-groups differences existed for change from PRE in atrogin-1 mRNA (p = 0.018) at the POST1 time point (EPC: − 19.7 +/- 8.1%, sham: + 7.7 +/- 5.9%) and atrogin-1 protein concentration (p = 0.013) at the POST2 time point (EPC: − 31.8 +/- 7.5%, sham: + 96.0 +/- 34.7%). In addition, change from PRE in poly-Ub proteins was significantly different between groups at both the POST1 (EPC: − 26.0 +/- 10.3%, sham: + 34.8 +/- 28.5%; p = 0.046) and POST2 (EPC: − 33.7 +/- 17.2%, sham: + 21.4 +/- 14.9%; p = 0.037) time points.
Conclusions: EPC when used concurrently with HIIT and in subsequent recovery days reduces skeletal muscle markers of proteolysis.