Glutamine and carbohydrate supplements reduce ammonemia increase during endurance field exercise

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Bibliographic Details
Title translated into German:Glutamin- und Kohlenhydratergänzungspräparate reduzieren die Zunahme der Blut-Ammoniakkonzentration während Ausdauerbelastungen
Author:Carvalho-Peixoto, Jacqueline; Alves, Robson Cardilo; Cameron, Luiz-Cláudio
Published in:Applied physiology, nutrition, and metabolism
Published:32 (2007), 6, S. 1186-1190, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Electronic resource (online) Print resource
ISSN:1715-5312, 1715-5320
Online Access:
Identification number:PU201802000948

Author's abstract

Blood ammonia concentration increases during endurance exercise and has been proposed as a cause for both peripheral and central fatigue. We examined the impact of glutamine and (or) carbohydrate supplementation on ammonemia in high-level runners. Fifteen men in pre-competitive training ran 120 min (~34 km) outdoors on 4 occasions. On the first day, the 15 athletes ran without the use of supplements and blood samples were taken every 30 min. After that, each day for 4 d before the next 3 exercise trials, we supplemented the athletes’ normal diets in bolus with carbohydrate (1 g•kg–1•d–1), glutamine (70 mg•kg–1•d–1), or a combination of both in a double-blind study. Blood ammonia level was determined before the run and every 30 min during the run. During the control trial ammonia increased progressively to approximately 70% above rest concentration. Following supplementation, independent of treatment, ammonia was not different (p > 0.05) for the first 60 min, but for the second hour it was lower than in the control (p < 0.05). Supplementation in high-level, endurance athletes reduced the accumulation of blood ammonia during prolonged, strenuous exercise in a field situation.