Exercise and MEF2–HDAC interactions
Deutscher übersetzter Titel: | Körperliche Belastung und MEF2–HDAC-Interaktionen |
---|---|
Autor: | McGee, Sean L. |
Erschienen in: | Applied physiology, nutrition, and metabolism |
Veröffentlicht: | 32 (2007), 5, S. 852-856, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 1715-5312, 1715-5320 |
DOI: | 10.1139/H07-082 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201801000849 |
Quelle: | BISp |
Abstract des Autors
Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5′-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.