Temporal changes in physiology and haematology in response to high- and micro-doses of recombinant human erythropoietin

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Deutscher übersetzter Titel:Zeitliche Veränderungen der Physiologie und Hämatologie nach hohen und sehr geringen rhEPO-Dosen
Autor:Clark, Bradley; Woolford, Sarah M.; Eastwood, Annette; Sharpe, Ken; Barnes, Peter G.; Gore, Christopher J.
Erschienen in:Drug testing and analysis
Veröffentlicht:9 (2017), 9/10, S. 1561-1571, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Elektronische Ressource (online) Gedruckte Ressource
Sprache:Englisch
ISSN:1942-7603, 1942-7611
DOI:10.1002/dta.2176
Schlagworte:
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Erfassungsnummer:PU201801000508
Quelle:BISp
id PU201801000508
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last_indexed 2022-08-30T11:01:31Z
first_indexed 2018-01-21T15:40:29Z
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subformat Zeitschriftenartikel
hierarchy_top_id JO00000100376
hierarchy_parent_id JOI201754800100376
hierarchy_top_title Drug testing and analysis
hierarchy_parent_title Drug testing and analysis, 2017, 9/10
is_hierarchy_id PU201801000508
is_hierarchy_title Temporal changes in physiology and haematology in response to high- and micro-doses of recombinant human erythropoietin
hierarchy_sequence 1561
recordtype bisparticle
publishDate 2017
publishDate_facet 2017
language eng
title Temporal changes in physiology and haematology in response to high- and micro-doses of recombinant human erythropoietin
spellingShingle Temporal changes in physiology and haematology in response to high- and micro-doses of recombinant human erythropoietin
Biochemie
Blut
Blutuntersuchung
Doping
Dopinganalyse
Dopingbekämpfung
Dopingnachweis
Dosierung
Erythropoetin
Hämatologie
Hämoglobin
title_sort temporal changes in physiology and haematology in response to high and microdoses of recombinant human erythropoietin
title_short Temporal changes in physiology and haematology in response to high- and micro-doses of recombinant human erythropoietin
title_alt Zeitliche Veränderungen der Physiologie und Hämatologie nach hohen und sehr geringen rhEPO-Dosen
title_alt_lang deu
media_type Elektronische Ressource (online)
Gedruckte Ressource
city Chichester
abstract There is evidence to suggest athletes have adopted recombinant human erythropoietin (rHuEPO) dosing regimens that diminish the likelihood of being caught by direct detection techniques. However, the temporal response in physiology, performance, and Athlete Biological Passport (ABP) parameters to such regimens is not clearly understood. Participants were assigned to a high-dose only group (HIGH, n = 8, six rHuEPO doses of 250 IU/kg over two weeks), a combined high micro-dose group (COMB, n = 8, high-dose plus nine rHuEPO micro-doses over a further three weeks), or one of two placebo control groups who received saline in the same pattern as the HIGH (HIGH-PLACEBO, n = 4) or COMB (COMB-PLACEBO, n = 4) groups. Temporal changes in physiology and performance were tracked by graded exercise test (GXT) and haemoglobin mass assessment at baseline, after high dose, after micro-dose (COMB and COMB-PLACEBO only) and after a four-week washout. Venous blood samples were collected throughout the baseline, rHuEPO administration, and washout periods to determine the haematological and ABP response to each dosing regimen. Physiological adaptations induced by a two-week rHuEPO high-dose were maintained by rHuEPO micro-dosing for at least three weeks. However, all participants administered rHuEPO registered at least one suspicious ABP value during the administration or washout periods. These results indicate there is sufficient sensitivity in the ABP to detect use of high rHuEPO doping regimens in athletic populations and they provide important empirical examples for use by anti-doping experts.
abstract_lang eng
abstract_type author
author2 Clark, Bradley
Woolford, Sarah M.
Eastwood, Annette
Sharpe, Ken
Barnes, Peter G.
Gore, Christopher J.
author_facet Clark, Bradley
Woolford, Sarah M.
Eastwood, Annette
Sharpe, Ken
Barnes, Peter G.
Gore, Christopher J.
author2-role Autor
Autor
Autor
Autor
Autor
Autor
author2-authorityid P362506





author_author_facet Clark, Bradley
Woolford, Sarah M.
Eastwood, Annette
Sharpe, Ken
Barnes, Peter G.
Gore, Christopher J.
author2-synonym Clark, Brad





author2_hierarchy_facet 0/Autor/
1/Autor/Clark, Bradley/
0/Autor/
1/Autor/Woolford, Sarah M./
0/Autor/
1/Autor/Eastwood, Annette/
0/Autor/
1/Autor/Sharpe, Ken/
0/Autor/
1/Autor/Barnes, Peter G./
0/Autor/
1/Autor/Gore, Christopher J./
doi 10.1002/dta.2176
spelling 10.1002/dta.2176
1942-7603
1942-7611
2462336-2
Biochemie
Blut
Blutuntersuchung
Doping
Dopinganalyse
Dopingbekämpfung
Dopingnachweis
Dosierung
Erythropoetin
Hämatologie
Hämoglobin
biochemistry
blood
blood test
doping
doping analysis
doping detection
dosage
erythropoietin
fight against doping
hematology
hemoglobin
Dopingmittel
Dopinganalyse
Dopinganalytik
EPO
Hämoglobinbestimmung
Bluthormonkonzentration
Blutanalyse
Temporal changes in physiology and haematology in response to high- and micro-doses of recombinant human erythropoietin
PU201801000508
201801000508
url https://dx.doi.org/10.1002/dta.2176
url-type fulltext
url-free 1
free_access 1
issn 1942-7603
1942-7611
zdb 2462336-2
location_hierarchy_facet 0/Großbritannien/
1/Großbritannien/England/
topic Biochemie
Blut
Blutuntersuchung
Doping
Dopinganalyse
Dopingbekämpfung
Dopingnachweis
Dosierung
Erythropoetin
Hämatologie
Hämoglobin
topic_facet Biochemie
Blut
Blutuntersuchung
Doping
Dopinganalyse
Dopingbekämpfung
Dopingnachweis
Dosierung
Erythropoetin
Hämatologie
Hämoglobin
topic_en biochemistry
blood
blood test
doping
doping analysis
doping detection
dosage
erythropoietin
fight against doping
hematology
hemoglobin
topic_en_facet biochemistry
blood
blood test
doping
doping analysis
doping detection
dosage
erythropoietin
fight against doping
hematology
hemoglobin
synonym Dopingmittel
Dopinganalyse
Dopinganalytik
EPO
Hämoglobinbestimmung
Bluthormonkonzentration
Blutanalyse
journal_facet Drug testing and analysis
container_title Drug testing and analysis
container_volume 9
container_issue 9/10
container_start_page S. 1561-1571
has_references 1
institution BISp
journal_fac JO00000100376
journal_year 2017
journal_issue 9/10
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score 13,2632065