Running exercise in obese pregnancies prevents IL-6 trans-signaling in male offspring

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Deutscher übersetzter Titel:Lauftraining bei adipösen Schwangerschaften verhindert IL-6-Trans-Signalübertragung bei männlichen Nachkommen
Autor:Bae-Gartz, Inga; Janoschek, Ruth; Kloppe, Cora-Sophia; Vohlen, Christina; Roels, Frederik; Oberthür, Andre; Alejandre Alacazar, Miguel Angel; Lippach, Gregor; Muether, Philipp S.; Dinger, Katharina; Ferrari, Nina; Graf, Christine; Dötsch, Jörg; Hucklenbruch-Rother, Eva
Erschienen in:Medicine and science in sports and exercise
Veröffentlicht:48 (2016), 5, S. 829–838, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Elektronische Ressource (online) Gedruckte Ressource
Sprache:Englisch
ISSN:0195-9131, 1530-0315
DOI:10.1249/MSS.0000000000000835
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Erfassungsnummer:PU201712010413
Quelle:BISp

Abstract des Autors

Purpose: Maternal obesity is known to predispose the offspring to impaired glucose metabolism and obesity associated with low-grade inflammation and hypothalamic dysfunction. Because preventive approaches in this context are missing to date, we aimed to identify molecular mechanisms in the offspring that are affected by maternal exercise during pregnancy.
Methods: Diet-induced obese mouse dams were divided into a sedentary obese (high-fat diet [HFD]) group and an obese intervention (HFD–running intervention [RUN]) group, which performed voluntary wheel running throughout gestation. Male offspring were compared with the offspring of a sedentary lean control group at postnatal day 21.
Results: HFD and HFD-RUN offspring showed increased body weight and white adipose tissue mass. Glucose tolerance testing showed mild impairment only in HFD offspring. Serum interleukin-6 (IL-6) levels, hypothalamic and white adipose tissue IL-6 gene expressions, and phosphorylation of signal transducer and activator of transcription 3 in HFD offspring were significantly increased, whereas HFD-RUN was protected against these changes. The altered hypothalamic global gene expression in HFD offspring showed partial normalization in HFD-RUN offspring, especially with respect to IL-6 action.
Conclusion: Maternal exercise in obese pregnancies effectively reduces IL-6 trans-signaling and might be the underlying mechanism for the amelioration of glucose metabolism at postnatal day 21 independent of body composition.