Urinary steroid profile in females : the impact of menstrual cycle and emergency contraceptives
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| Deutscher übersetzter Titel: | Urinsteroidprofil bei Frauen : Einfluss von Menstruationszyklus und Notfall-Empfängnisverhütungsmitteln |
|---|---|
| Autor: | Mullen, Jenny E.; Thörngren, John-Olof ; Schulze, Jenny J.; Ericsson, Magnus; Gårevik, Nina; Lehtihet, Mikael; Ekström, Lena |
| Erschienen in: | Drug testing and analysis |
| Veröffentlicht: | 9 (2017), 7/8, S. 1034-1042, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 1942-7603, 1942-7611 |
| DOI: | 10.1002/dta.2121 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201710008544 |
| Quelle: | BISp |
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PU201710008544 |
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db |
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Literatur |
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2022-08-29T10:10:18Z |
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2017-10-09T17:02:39Z |
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BISp |
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Zeitschriftenartikel |
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JO00000100376 |
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JOI20170efa0100376 |
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Drug testing and analysis |
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Drug testing and analysis, 2017, 7/8 |
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PU201710008544 |
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Urinary steroid profile in females : the impact of menstrual cycle and emergency contraceptives |
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1034 |
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bisparticle |
| publishDate |
2017 |
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2017 |
| language |
eng |
| title |
Urinary steroid profile in females : the impact of menstrual cycle and emergency contraceptives |
| spellingShingle |
Urinary steroid profile in females : the impact of menstrual cycle and emergency contraceptives Biochemie Doping Dopinganalyse Dopingbekämpfung Dopingnachweis Empfängnisverhütung Enzym Epitestosteron Frau Menstruationszyklus Metabolit Steroid Testosteron Urin Urinuntersuchung |
| title_sort |
urinary steroid profile in females the impact of menstrual cycle and emergency contraceptives |
| title_short |
Urinary steroid profile in females : the impact of menstrual cycle and emergency contraceptives |
| title_alt |
Urinsteroidprofil bei Frauen : Einfluss von Menstruationszyklus und Notfall-Empfängnisverhütungsmitteln |
| title_alt_lang |
deu |
| media_type |
Elektronische Ressource (online) Gedruckte Ressource |
| city |
Chichester |
| abstract |
Today's doping tests involving longitudinal monitoring of steroid profiles are difficult in women. Women have more complex hormonal fluctuations than men and commonly take drugs such as hormonal contraceptives that are shown to affect biomarkers used in these doping tests. In this study, we followed six women's urinary steroid profile during one menstrual cycle, including both glucuronides and sulfate conjugated fractions. Additionally, we studied what happens to the steroidal module of the Athlete Biological Passport (ABP) after administration of an emergency contraceptive (levonorgestrel, NorLevo®). The study shows that there are large individual variations in all metabolites included in the ABP and that the administration of emergency contraceptives may lead to suspicious steroid profile findings in the ABP. Urinary epitestosterone concentration increased during the menstrual cycle, leading to a decrease in the testosterone/epitestosterone ratio. The ratios followed in the ABP varied widely throughout the menstrual cycle, the coefficient of variation (CV) ranging from 4 to 99%. There was a 3-fold decrease in epitestosterone 24 h post administration of the emergency contraceptive pill and androsterone, etiocholanolone, and 5β- androstan-3α,17β-diol concentrations decreased about 2-fold. When analyzed with the ABP software, one of the six women had an atypical profile after taking the emergency contraceptive. Furthermore, we could not find any alterations in excretion routes (i.e., if the metabolites are excreted as glucuronide or sulfate conjugates) during the menstrual cycle or after administration of emergency contraceptive, indicating no direct effect on phase II enzymes. |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Mullen, Jenny E. Thörngren, John-Olof Schulze, Jenny J. Ericsson, Magnus Gårevik, Nina Lehtihet, Mikael Ekström, Lena |
| author_facet |
Mullen, Jenny E. Thörngren, John-Olof Schulze, Jenny J. Ericsson, Magnus Gårevik, Nina Lehtihet, Mikael Ekström, Lena |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor |
| author2-authorityid |
P200867 P358726 P150980 |
| author_author_facet |
Mullen, Jenny E. Thörngren, John-Olof Schulze, Jenny J. Ericsson, Magnus Gårevik, Nina Lehtihet, Mikael Ekström, Lena |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Mullen, Jenny E./ 0/Autor/ 1/Autor/Thörngren, John-Olof / 0/Autor/ 1/Autor/Schulze, Jenny J./ 0/Autor/ 1/Autor/Ericsson, Magnus/ 0/Autor/ 1/Autor/Gårevik, Nina/ 0/Autor/ 1/Autor/Lehtihet, Mikael/ 0/Autor/ 1/Autor/Ekström, Lena/ |
| doi |
10.1002/dta.2121 |
| spelling |
10.1002/dta.2121 1942-7603 1942-7611 2462336-2 Biochemie Doping Dopinganalyse Dopingbekämpfung Dopingnachweis Empfängnisverhütung Enzym Epitestosteron Frau Menstruationszyklus Metabolit Steroid Testosteron Urin Urinuntersuchung biochemistry contraception doping doping analysis doping detection enzyme epitestosterone fight against doping menstrual cycle metabolite steroid testosterone urine urine examination woman Dopingmittel Dopinganalyse Dopinganalytik Antikonzeptivum Urinhormonausscheidung Urinhormonkonzentration Urinhormonmetabolitenkonzentration Diskriminierung, geschlechtliche Frauengymnastik Frauentraining Hausfrau Stoffwechselprodukt birth control Urinary steroid profile in females : the impact of menstrual cycle and emergency contraceptives PU201710008544 201710008544 |
| url |
https://dx.doi.org/10.1002/dta.2121 |
| url-type |
fulltext |
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1 |
| free_access |
1 |
| issn |
1942-7603 1942-7611 |
| zdb |
2462336-2 |
| location_hierarchy_facet |
0/Großbritannien/ 1/Großbritannien/England/ 0/Großbritannien/ 1/Großbritannien/England/ 0/Großbritannien/ 1/Großbritannien/England/ 0/Großbritannien/ 1/Großbritannien/England/ |
| topic |
Biochemie Doping Dopinganalyse Dopingbekämpfung Dopingnachweis Empfängnisverhütung Enzym Epitestosteron Frau Menstruationszyklus Metabolit Steroid Testosteron Urin Urinuntersuchung |
| topic_facet |
Biochemie Doping Dopinganalyse Dopingbekämpfung Dopingnachweis Empfängnisverhütung Enzym Epitestosteron Frau Menstruationszyklus Metabolit Steroid Testosteron Urin Urinuntersuchung |
| topic_en |
biochemistry contraception doping doping analysis doping detection enzyme epitestosterone fight against doping menstrual cycle metabolite steroid testosterone urine urine examination woman |
| topic_en_facet |
biochemistry contraception doping doping analysis doping detection enzyme epitestosterone fight against doping menstrual cycle metabolite steroid testosterone urine urine examination woman |
| synonym |
Dopingmittel Dopinganalyse Dopinganalytik Antikonzeptivum Urinhormonausscheidung Urinhormonkonzentration Urinhormonmetabolitenkonzentration Diskriminierung, geschlechtliche Frauengymnastik Frauentraining Hausfrau Stoffwechselprodukt |
| synonym_en |
birth control |
| journal_facet |
Drug testing and analysis |
| container_title |
Drug testing and analysis |
| container_volume |
9 |
| container_issue |
7/8 |
| container_start_page |
S. 1034-1042 |
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1 |
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BISp |
| journal_fac |
JO00000100376 |
| journal_year |
2017 |
| journal_issue |
7/8 |
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1797309750492266496 |
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13,050436 |