TY  - JOUR
AU  - Hiura, Mikio
A2  - Hiura, Mikio
A2  - Sakata, Muneyuki
A2  - Ishii, Kenji
A2  - Toyohara, Jun
A2  - Oda, Keiichi
A2  - Nariai, Tadashi
A2  - Ishiwata, Kiichi
DB  - BISp
DP  - BISp
KW  - Ausdauerbelastung
KW  - Belastung, erschöpfende
KW  - Belastungsintensität
KW  - Belastungswahrnehmung
KW  - Ermüdung
KW  - Erschöpfung
KW  - Fahrradergometerbelastung
KW  - Fahrradergometrie
KW  - Gehirn
KW  - Neurophysiologie
KW  - Pilotstudie
KW  - Rezeptor
KW  - Sportmedizin
LA  - eng
TI  - Central μ-opioidergic system activation evoked by heavy and severe-intensity cycling exercise in humans : a pilot study using positron emission tomography with 11C-carfentanil
TT  - Zentrale Aktivierung des μ-opioidergen Systems durch schwere und sehr schwere Radfahrbelastung beim Menschen : eine Pilotstudie unter Verwendung der Positronen-Emissions-Tomographie mit 11C-Carfentanil
PY  - 2017
N2  - The central opioid receptor system likely contributes to the mechanism underlying the changes in affect elicited by exercise. Our aim was to use positron emission tomography (PET) to test whether exercise intensity influences activation of the μ-opioid receptor system in the brain, and whether changes in opioid receptor activation correlate with exercise-induced changes in affect. 7 healthy young male subjects (23±2 years) performed 20-min constant-load cycling exercises at heavy (ExH) and severe-intensity (ExS), and PET was performed using [11C]carfentanil as a tracer before and after each exercise. Exercise elicited the μ-opioidergic system activation in the large areas of the limbic system, particularly in the insular cortex, and cerebellum. Of note, deactivation of the μ-opioidergic system in the pituitary gland was identified as a specific finding in ExS, which evoked a distinctive sensation of fatigue. Within these brain areas, μ-opioid receptor activation correlated positively with increased positive affect (R2=0.67–0.95) in ExH and negative affect (R2=0.63–0.77) in ExS. These findings suggest that central μ-opioidergic neurotransmission evoked by continuous exercise is discriminated by work intensity. Notably, we also observed a possible contribution of the central μ-opioidergic system to the development of the sensation of fatigue during exhaustive exercise.
L2  - https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0042-114779.pdf
L2  - https://dx.doi.org/10.1055/s-0042-114779
DO  - 10.1055/s-0042-114779
SP  - S. 19-26
SN  - 0172-4622
JO  - International journal of sports medicine
IS  - 1
VL  - 38
M3  - Elektronische Ressource (online)
M3  - Gedruckte Ressource
ID  - PU201701000859
ER  -