Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion
Gespeichert in:
| Deutscher übersetzter Titel: | Sytematische Literaturübersicht zu klinischen Studien zur Untersuchung der Biomarker von Gehirnverletzungen bei Sportlern nach sportbezogener Gehirnerschütterung |
|---|---|
| Autor: | Papa, Linda; Ramia, Michelle M.; Edwards, Damyan; Johnson, Brian D.; Slobounov, Semyon M. |
| Erschienen in: | Journal of neurotrauma |
| Veröffentlicht: | 32 (2015), 12, S. 661–673, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0897-7151, 1557-9042 |
| DOI: | 10.1089/neu.2014.3655 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201606003321 |
| Quelle: | BISp |
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PU201606003321 |
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db |
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Literatur |
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2016-06-21T11:09:48Z |
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Zeitschriftenartikel |
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JO00000202095 |
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JOI201500120202095 |
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Journal of neurotrauma |
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Journal of neurotrauma, 2015, 12 |
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PU201606003321 |
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Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion |
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bisparticle |
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2015 |
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2015 |
| language |
eng |
| title |
Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion |
| spellingShingle |
Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion Albumin Basketballspiel Boxen Feldhockey Fußballspiel Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Kortisol Literaturübersicht Markersubstanz Neurologie Schwimmsport Schädelhirnverletzung Sportmedizin Sporttraumatologie Straßenradsport Zustand, posttraumatischer |
| title_sort |
systematic review of clinical studies examining biomarkers of brain injury in athletes after sportsrelated concussion |
| title_short |
Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion |
| title_alt |
Sytematische Literaturübersicht zu klinischen Studien zur Untersuchung der Biomarker von Gehirnverletzungen bei Sportlern nach sportbezogener Gehirnerschütterung |
| title_alt_lang |
deu |
| media_type |
Elektronische Ressource (online) Gedruckte Ressource |
| city |
Larchmont (N.Y.) |
| abstract |
The aim of this study was to systematically review clinical studies examining biofluid biomarkers of brain injury for concussion in athletes. Data sources included PubMed, MEDLINE, and the Cochrane Database from 1966 to October 2013. Studies were included if they recruited athletes participating in organized sports who experienced concussion or head injury during a sports-related activity and had brain injury biomarkers measured. Acceptable research designs included experimental, observational, and case-control studies. Review articles, opinion papers, and editorials were excluded. After title and abstract screening of potential articles, full texts were independently reviewed to identify articles that met inclusion criteria. A composite evidentiary table was then constructed and documented the study title, design, population, methods, sample size, outcome measures, and results. The search identified 52 publications, of which 13 were selected and critically reviewed. All of the included studies were prospective and were published either in or after the year 2000. Sports included boxing (six studies), soccer (five studies), running/jogging (two studies), hockey (one study), basketball (one study), cycling (one study), and swimming (one study). The majority of studies (92%) had fewer than 100 patients. Three studies (23%) evaluated biomarkers in cerebrospinal fluid (CSF), one in both serum and CSF, and 10 (77%) in serum exclusively. There were 11 different biomarkers assessed, including S100β, glial fibrillary acidic protein, neuron-specific enolase, tau, neurofilament light protein, amyloid beta, brain-derived neurotrophic factor, creatine kinase and heart-type fatty acid binding protein, prolactin, cortisol, and albumin. A handful of biomarkers showed a correlation with number of hits to the head (soccer), acceleration/deceleration forces (jumps, collisions, and falls), postconcussive symptoms, trauma to the body versus the head, and dynamics of different sports. Although there are no validated biomarkers for concussion as yet, there is potential for biomarkers to provide diagnostic, prognostic, and monitoring information postinjury. They could also be combined with neuroimaging to assess injury evolution and recovery. |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Papa, Linda Ramia, Michelle M. Edwards, Damyan Johnson, Brian D. Slobounov, Semyon M. |
| author_facet |
Papa, Linda Ramia, Michelle M. Edwards, Damyan Johnson, Brian D. Slobounov, Semyon M. |
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Autor Autor Autor Autor Autor |
| author2-authorityid |
|
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Papa, Linda Ramia, Michelle M. Edwards, Damyan Johnson, Brian D. Slobounov, Semyon M. |
| author2-synonym |
|
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0/Autor/ 1/Autor/Papa, Linda/ 0/Autor/ 1/Autor/Ramia, Michelle M./ 0/Autor/ 1/Autor/Edwards, Damyan/ 0/Autor/ 1/Autor/Johnson, Brian D./ 0/Autor/ 1/Autor/Slobounov, Semyon M./ |
| doi |
10.1089/neu.2014.3655 |
| spelling |
10.1089/neu.2014.3655 0897-7151 1557-9042 645092-1 Albumin Basketballspiel Boxen Feldhockey Fußballspiel Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Kortisol Literaturübersicht Markersubstanz Neurologie Schwimmsport Schädelhirnverletzung Sportmedizin Sporttraumatologie Straßenradsport Zustand, posttraumatischer basketball boxing brain brain function brain injury concussion of the brain coomotio cerebri cortisol craniocerebral injury field hockey literature survey marker substance neurology posttraumatic state road racing (CYCLG) soccer sports medicine sport traumatology swimming Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Traumatologie Hirnszintigraphie Hirnkontusion Gehirnfunktion Hirngeschädigter Hirnschaden Bibliographie Literaturüberblick Literaturstudie Literatursammlung Boxer Boxsport Amateurboxer Boxstellung Boxtechnik Doppelendball Gerader Stoss Linksauslage Maisbirne Punchingball Rechtsauslage Ringarzt Leberhaken Sandsack Fußball Fußballspieler Fußballsport Fußballmannschaft Fußballmeisterschaft Fußballstiefel Fußballtraining Fußballweltmeisterschaft Mittelstürmer Schiedsrichterball Mexiko City 1986 Frauenfußball Feldhockeyspieler Hockey Hockeyspieler Eckschlag Hockeyball Hockeyschläger Kleinfeldhockey Hockeystock Hockeyspiel Basketball Basketballspieler Centerspieler Korb Sprungball Center Straßenrennen Straßenrennsport Schwimmsportler Sportschwimmen Wettkampfschwimmen Wettkampfschwimmer Schwimmerin Schwimmfest Schwimmtechnik Schwimmtraining Schwimmverein Schwimmer Schwimmwettkampf Cortisol traumatology of sport brain concussion cerebral commotion commotio cerebri injury of the brain bibliography Systematic review of clinical studies examining biomarkers of brain injury in athletes after sports-related concussion PU201606003321 201606003321 |
| url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426313/ https://dx.doi.org/10.1089/neu.2014.3655 |
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fulltext fulltext |
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1 |
| issn |
0897-7151 1557-9042 |
| zdb |
645092-1 |
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0/USA/ 1/USA/New York/ |
| topic |
Albumin Basketballspiel Boxen Feldhockey Fußballspiel Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Kortisol Literaturübersicht Markersubstanz Neurologie Schwimmsport Schädelhirnverletzung Sportmedizin Sporttraumatologie Straßenradsport Zustand, posttraumatischer |
| topic_facet |
Albumin Basketballspiel Boxen Feldhockey Fußballspiel Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Kortisol Literaturübersicht Markersubstanz Neurologie Schwimmsport Schädelhirnverletzung Sportmedizin Sporttraumatologie Straßenradsport Zustand, posttraumatischer |
| topic_en |
basketball boxing brain brain function brain injury concussion of the brain coomotio cerebri cortisol craniocerebral injury field hockey literature survey marker substance neurology posttraumatic state road racing (CYCLG) soccer sports medicine sport traumatology swimming |
| topic_en_facet |
basketball boxing brain brain function brain injury concussion of the brain coomotio cerebri cortisol craniocerebral injury field hockey literature survey marker substance neurology posttraumatic state road racing (CYCLG) soccer sports medicine sport traumatology swimming |
| synonym |
Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Traumatologie Hirnszintigraphie Hirnkontusion Gehirnfunktion Hirngeschädigter Hirnschaden Bibliographie Literaturüberblick Literaturstudie Literatursammlung Boxer Boxsport Amateurboxer Boxstellung Boxtechnik Doppelendball Gerader Stoss Linksauslage Maisbirne Punchingball Rechtsauslage Ringarzt Leberhaken Sandsack Fußball Fußballspieler Fußballsport Fußballmannschaft Fußballmeisterschaft Fußballstiefel Fußballtraining Fußballweltmeisterschaft Mittelstürmer Schiedsrichterball Mexiko City 1986 Frauenfußball Feldhockeyspieler Hockey Hockeyspieler Eckschlag Hockeyball Hockeyschläger Kleinfeldhockey Hockeystock Hockeyspiel Basketball Basketballspieler Centerspieler Korb Sprungball Center Straßenrennen Straßenrennsport Schwimmsportler Sportschwimmen Wettkampfschwimmen Wettkampfschwimmer Schwimmerin Schwimmfest Schwimmtechnik Schwimmtraining Schwimmverein Schwimmer Schwimmwettkampf Cortisol |
| synonym_en |
traumatology of sport brain concussion cerebral commotion commotio cerebri injury of the brain bibliography |
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Journal of neurotrauma |
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Journal of neurotrauma |
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32 |
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12 |
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S. 661–673 |
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BISp |
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2015 |
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