TY  - JOUR
AU  - Wahl, Patrick
A2  - Wahl, Patrick
A2  - Yue, Zengyuan
A2  - Zinner, Christoph
A2  - Bloch, Wilhelm
A2  - Mester, Joachim
DB  - BISp
DP  - BISp
KW  - Ausdauertraining
KW  - Belastung
KW  - Belastungsintensität
KW  - Blutlaktat
KW  - Erythrozyt
KW  - Leistungsphysiologie
KW  - Muskellaktat
KW  - Sportmedizin
KW  - Trainingswirkung
LA  - eng
TI  - A mathematical model for lactate transport to red blood cells
TT  - Ein mathematisches Modell für den Laktattransport zu den roten Blutkörperchen
PY  - 2011
N2  - A simple mathematical model for the transport of lactate from plasma to red blood cells (RBCs) during and after exercise is proposed based on our experimental studies for the lactate concentrations in RBCs and in plasma. In addition to the influx associated with the plasma-to-RBC lactate concentration gradient, it is argued that an efflux must exist. The efflux rate is assumed to be proportional to the lactate concentration in RBCs. This simple model is justified by the comparison between the model-predicted results and observations: For all 33 cases (11 subjects and 3 different warm-up conditions), the model-predicted time courses of lactate concentrations in RBC are generally in good agreement with observations, and the model-predicted ratios between lactate concentrations in RBCs and in plasma at the peak of lactate concentration in RBCs are very close to the observed values. Two constants, the influx rate coefficient C 1 and the efflux rate coefficient C 2, are involved in the present model. They are determined by the best fit to observations. Although the exact electro-chemical mechanism for the efflux remains to be figured out in the future research, the good agreement of the present model with observations suggests that the efflux must get stronger as the lactate concentration in RBCs increases. The physiological meanings of C 1 and C 2 as well as their potential applications are discussed.    Verf.-Referat
L2  - https://dx.doi.org/10.1007/s12576-010-0125-8
DO  - 10.1007/s12576-010-0125-8
SP  - S. 93-102
SN  - 1880-6546
JO  - The journal of physiological sciences
IS  - 2
VL  - 61
M3  - Elektronische Ressource (online)
M3  - Gedruckte Ressource
ID  - PU201408008261
ER  -