TY  - JOUR
AU  - Sawczuk, Marek
A2  - Sawczuk, Marek
A2  - Maciejewska-Karłowska, Agnieszka
A2  - Cieszczyk, P.
A2  - Skotarczak, Bogumila
A2  - Ficek, Krzysztof
DB  - BISp
DP  - BISp
KW  - Adrenalin
KW  - Ausdauer
KW  - Ausdauersport
KW  - Betarezeptor
KW  - Leistungsfähigkeit, kardiopulmonale
KW  - Leistungsfähigkeit, kardiovaskuläre
KW  - Polymorphismus
KW  - Rezeptor
KW  - Sportmedizin
KW  - Sportwissenschaft
LA  - eng
TI  - Association of the ADRB2 Gly16Arg and Glu27Gln polymorphisms with athlete status
TT  - Verbindung des ADRB2 Gly16Arg und des Glu27Gln Polymorphismus mit dem Status des Athleten
PY  - 2013
N2  - The β-adrenergic receptors (β-ARs) have known functional roles in cardiovascular and pulmonary responses as well as the appropriate substrate metabolism required for athletic ability. Thus, the β-AR genes are plausible candidates for the variations observed in strength/power and endurance performance levels. The aims of the present study were to compare the frequency distribution of the ADRB2 Gly16Arg and ADRB2 Glu27Gln polymorphisms among athletes of sports with different metabolic and cardiopulmonary demands (endurance vs. strength/power) and to test the association between the Gly16Arg and Glu27Gln genotypes and athlete status. The study was performed in a group of 223 Polish athletes of the highest nationally competitive standard (123 endurance-oriented athletes and 100 strength/power athletes). Control samples were prepared from 354 unrelated, sedentary volunteers. The χ2 test of independence revealed that the frequencies of the Gly16 and Glu27 alleles were significantly higher in the strength/power athletes than in the controls (69.0% vs. 59.7%; df = 1, P = 0.017 and 51% vs. 41.5%; df = 1 P = 0.017, respectively). The study showed that ADRB2 Gly16Arg and Glu27Gln markers are associated with athlete status in Polish athletes. An excess of Gly16 and Glu27 alleles and the Gly16:Glu27 haplotype observed in the strength/power athlete subgroup suggests that the Gly16 and Glu27 alleles might increase the probability of becoming a strength/power athlete rather than an endurance-oriented athlete. Verf.-Referat
L2  - https://dx.doi.org/10.1080/02640414.2013.786184
DO  - 10.1080/02640414.2013.786184
SP  - S. 1535-1544
SN  - 0264-0414
JO  - Journal of sports sciences
IS  - 14
VL  - 31
M3  - Gedruckte Ressource
ID  - PU201312008810
ER  -